A Prospective Randomized Controlled Trial Investigating Embryonic Development and Clinical Outcome After Using Ca2+ Ionophore in Cases With Previous Fertilization Arrest
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Blastocyst formation rate
研究概览
简要总结
We aimed to investigate the efficiency of chemical oocyte activation using readymade Ca2+ ionophore on cases with previously cancelled cases due to fertilization arrest at pronuclear stage i.e: cleavage failure to find out if there is any improvement in embryonic developmental stages.
详细描述
Many studies reported that Ca2+ ionophore has a positive effect on embryo development in cases with complete or partial fertilization failure. However, only one preliminary report suggested a beneficial effect of Ca2+ ionophore activation in four cases with fertilization arrest.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with previous history of complete fertilization arrest.
- •ovarian stimulation with the GnRH agonist and recombinant FSH in a long protocol.
排除标准
- •Female age >40 years
结局指标
主要结局
Blastocyst formation rate
时间窗: 5 to 7days post oocyte retrival
Defined as the total number of blastocyst / total number of cleaved Embryos
次要结局
未报告次要终点
研究者
Yasmin Magdi
Senior clinical embryologist
Dar AlMaraa Center