The Impact of Two Days of Bed Rest Versus Two Days of Habitual Activity on Insulin Sensitivity and Cumulative Muscle Protein Synthesis in Healthy Young Males
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Change in whole-body insulin sensitivity
研究概览
简要总结
The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
详细描述
To study the mechanisms underlying inactivity-induced muscle atrophy, the impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged 18-40
排除标准
- •Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)
- •Any diagnosed cardiovascular disease (e.g. deep vein thrombosis or hypertension)
- •Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).
- •A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
- •Any known disorders in muscle metabolism
- •Regular use of nutritional supplements (i.e. ingestion more than twice per week during the last month)
- •Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
- •Allergy to lidocaine
- •Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)
研究组 & 干预措施
Habitual activity and 2 days bed rest
Participants will undergo 2 days of habitual activity and 2 days bed rest
干预措施: Habitual activity (Behavioral)
Habitual activity and 2 days bed rest
Participants will undergo 2 days of habitual activity and 2 days bed rest
干预措施: Bed rest (Behavioral)
结局指标
主要结局
Change in whole-body insulin sensitivity
时间窗: During 2 days of habitual physical activity and 2 days of bed rest. Blood glucose and insulin are monitored for 2 hours following ingestion of a standardized meal
Change in whole-body insulin sensitivity via meal tolerance test
次要结局
- Change in muscle volume(Immediately before and immediately after the 2-day bed rest period)
- Change in cumulative muscle protein synthesis(During 2 days of habitual physical activity and 2 days of bed rest)
- Change in continuous glucose(Continuous glucose, during the 2 days of habitual activity and 2 days of bed rest)