Saccular Dilatation, Endolymphatic Hydrops and Vestibular Schwannoma : is Vertigo Really Correlated to the Tumor ? A Retrospective Study Based on FIESTA-C Sequence Using a 3 Tesla MRI
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 185
- 试验地点
- 1
- 主要终点
- Presence or absence of height and width of the saccule on MRI.
研究概览
简要总结
Endolymphatic hydrops is well known of the lay public in its primary form that is Ménière disease. Nowadays, the best w ay to approach it in vivo, is to use magnetic resonance imaging (MRI).
However, endolymphatic hydrops don't limit itself to its primary form but cover a whole range of pathologies.
The hypothesis is that patients with vestibular schwannomas are more likely to develop secondary saccular hydrops.
The aim is to compare high-resolution T2-weighted images of the saccule in patients followed up for vestibular schwannomas with healthy volunteers and histological sections from cadavers in order to identify its changes.
The secondary purpose of The protocol is to determine if vestibular and audiometric abnormalities could be related to this secondary hydrops more specifically than to the tumor size and localisation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age> 18,
- •Subject having benefited from an MRI with T2 high-resolution 3D sequence (FIESA) in the context of the diagnosis of vestibular schwannoma between 2008 and 2017 at the University Hospitals of Strasbourg,
- •Subject who has agreed to the use of medical data for the purposes of this research.
排除标准
- •Refusal of the patient to participate in the study
- •Insufficient imaging data,
- •Tumors already treated,
- •Atypical tumors with uncertain diagnosis, intra-labrinthic or intra-labyrinthine schwannomas, concomitant infectious or inflammatory pathology in the middle or inner ear.
- •Impossibility of giving the subject informed information (difficulty understanding the subject,)
- •Subject under the protection of justice
- •Subject under guardianship or curatorship
结局指标
主要结局
Presence or absence of height and width of the saccule on MRI.
时间窗: 1 hour after the realization of the MRI
次要结局
未报告次要终点