Predictors of employment status and work absenteeism in relapsing-remitting Multiple Sclerosis
Completed
- Conditions
- MSMultiple Sclerosis1000795110024450
- Registration Number
- NL-OMON47448
- Lead Sponsor
- ationaal MS Fonds
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 350
Inclusion Criteria
-Patients with a diagnosis of relapsing-remitting Multiple Sclerosis according to the McDonald criteria 2010 and healthy controls not diagnosed with any neurological, psychiatric or other chronic disorder
-18 years or older
-currently employed or within 3 years since their last employment
Exclusion Criteria
-co morbid psychiatric or neurological disorders
-substance abuse
-MS relapse within 1 month prior to the study visit
-unable to speak and/or read Dutch
-neurological impairment that might interfere with cognitive testing (e.g. upper limb weakness, dysarthria, vision worse than 20/70)
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The outcome variables include changes in employment status (i.e. stable versus<br /><br>deteriorated) and work absenteeism (i.e. days missed from work during a<br /><br>specified period) from baseline to endpoint</p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters include the predictor variables, i.e. cognitive<br /><br>performance and cognitive complaints, physical ability, psychological<br /><br>functioning (i.e. anxiety, depression, psychosocial stress, quality of life,<br /><br>fatigue, empathy, personality traits and coping strategies), gene set data,<br /><br>polygenetic risk score, and type of immunomodulatory treatment.</p><br>