Ethnic/Racial Differences in Metabolism and DNA Adduct Formation by 1,3-butadiene
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Butadiene-DNA adducts in different ethnic groups
研究概览
简要总结
The study will investigate the role of 1,3-butadiene metabolic activation and deactivation in lung cancer risk among various ethnic/racial groups. This project will require urine samples from smokers and nonsmokers from the three ethnic/racial groups recruited by the Clinical and Biomarker Core for the analysis of 1,3-butadiene DNA adducts. Data on nicotine intake (urinary TNE) in these subjects as well as in 400 lung cancer cases and 400 controls from Project 1 will be also required for this project.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •One of the three targeted ethnic groups:
- •Japanese American - two parents of Japanese descent
- •Non-Hispanic Whites - two parents of non-Hispanic white descent
- •Native Hawaiians will include individuals with at least one parent of Hawaiian descent;
- •Smoke 5 cigarettes per day over the past three months;
- •>21 years of age;
- •Consumes 14 or fewer drinks of alcohol per week;
- •Generally stable and good health (determined by review of medical history);
- •Able to provide written voluntary consent before performance of any study related procedure.
排除标准
- •Current use of other nicotine containing products for > 4 times per month (and no use of any nicotine-containing products except cigarettes for 2 weeks prior to their study visits);
- •Acute or uncontrolled medical or psychiatric conditions;
- •Currently taking any medications that affect relevant metabolic enzymes or anti- inflammatory medications such as ibuprofen (this will be reviewed by study investigators on a case-by-case basis);
- •Active infection (e.g., influenza, cold, respiratory infection, sinus infection) at the time of the visit;
- •Pregnant or nursing or planning on becoming pregnant during the study;
- •Unable to read and understand English.
结局指标
主要结局
Butadiene-DNA adducts in different ethnic groups
时间窗: Day 1 & 2
Investigate ethnic differences in butadiene-DNA adducts in smokers belonging to different ethnic groups.
Polymorphisms of carnicogen metabolizing genes
时间窗: Day 1 & 2
Examine how polymorphisms of carcinogen metabolizing genes influence metabolic inactivation, DNA adduct formation/repair, and toxicity of butadiene-derived epoxides.
Butadiene-DNA adduct load in smokers with lung cancer
时间窗: Day 1 & 2
Investigate the association between butadiene-DNA adduct load and lung cancer development in smokers.
次要结局
未报告次要终点