The Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) Trial - REEACT
- Conditions
- Depression
- Registration Number
- EUCTR2007-007645-12-GB
- Lead Sponsor
- niversity of York
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- Not specified
- Target Recruitment
- 600
Our target population will be adult patients, aged 18 and above with depression who are not currently in receipt of computerised CBT or specialist psychological therapy. Our inclusion threshold will be a score of >=10 on the PHQ9 depression severity instrument. This cut point is known to detect clinical depression (major depression) in a UK primary care population with sensitivity = 91.7% and specificity = 78.3%. We will also include patients with either co-morbid physical illness or co-morbid non-psychotic functional disorders, such as anxiety. We will include both incident and prevalent cases. In line with the pragmatic nature of this trial, we will reflect usual GP care and participants will be eligible to participate whether they are in receipt of antidepressant medication or not.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range
We will exclude patients who are actively suicidal; suffering psychotic symptoms; depressed in the post-natal period; or have recently suffered bereavement. Patients with previous treatment experience of CBT will not be excluded. We will exclude cases of psychotic depression, since computerised therapy is not recommended within NICE guidance, and are also unlikely to be recruited or randomised by general practitioners to receive computerised CBT, since they are unlikely to have sufficient equipoise in this case.
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method