A prospective clinical trial for the treatment of keratoconjunctivitis caused by microsporidia.
- Conditions
- Health Condition 1: null- Patients presenting with clinically diagnosed superficial epithelial microsporidial keratitis or keratoconjunctivitis.
- Registration Number
- CTRI/2011/11/002132
- Lead Sponsor
- Hyderabad Eye Research Foundation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 72
Patients presenting with clinically diagnosed superficial epithelial microsporidial keratitis or keratoconjunctivitis.
Minimum of 10 discrete epithelial or subepithelial lesions on presentation.
Must be able to read and sign an informed consent form or if the patient is under 18 years of age, the informed consent must be understood and signed by the patient?s parent or guardian.
Must agree to ensure compliance with the visit schedules and/or other requirements of the study, or the parents or guardians of patients less than 18 years of age must agree to ensure the above compliance.
Any clinically diagnosed case of superficial microsporidial keratoconjunctivitis with less than 10 discrete lesions.
Presence of stromal infiltrates at presentation.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time taken from the presentation to complete resolution of the clinical signs and symptoms (resolution is defined as absence of corneal lesion).Timepoint: All patients will be examined on day 0, 3, 7 and at weekly intervals until resolution of clinical signs and symptoms.
- Secondary Outcome Measures
Name Time Method Final visual acuity following resolution of symptoms. <br/ ><br> <br/ ><br>Residual corneal scarring. <br/ ><br> <br/ ><br>Side-effects, if any.Timepoint: All patients will be examined on day 0, 3, 7 and at weekly intervals until resolution of clinical signs and symptoms.