Effect of N_Acetylcysteine on Liver Functions in Donors in Living Donor Liver Transplantation
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Serum lactate
研究概览
简要总结
our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection. Several drugs have been investigation on liver regeneration , proven benefit of N-Acetylcysteine (NAC) on rats with steatohpatitis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I or II donors
- •healthy adult
排除标准
- •kidney, liver disease
- •any contraindications for organ donation
研究组 & 干预措施
NAC group
Group NC received NAC 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days
干预措施: N-Acetylecysteine (Drug)
Control group
Group C (Control group) will receive ringer acetate continuous infusion at same rate for 2 days.
干预措施: Placebo (Drug)
结局指标
主要结局
Serum lactate
时间窗: 24 hours postoperative
次要结局
未报告次要终点
研究者
Mona Ammar
Lecturer of anesthesia,intensive care and pain management
Ain Shams University