Effect of N_Acetylcysteine on Liver Functions in Donors in Living Donor Liver Transplantation
Overview
- Phase
- Phase 1
- Intervention
- N-Acetylecysteine
- Conditions
- Liver Transplant; Complications
- Sponsor
- Ain Shams University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Serum lactate
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection. Several drugs have been investigation on liver regeneration , proven benefit of N-Acetylcysteine (NAC) on rats with steatohpatitis
Investigators
Mona Ammar
Lecturer of anesthesia,intensive care and pain management
Ain Shams University
Eligibility Criteria
Inclusion Criteria
- •ASA I or II donors
- •healthy adult
Exclusion Criteria
- •kidney, liver disease
- •any contraindications for organ donation
Arms & Interventions
NAC group
Group NC received NAC 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days
Intervention: N-Acetylecysteine
Control group
Group C (Control group) will receive ringer acetate continuous infusion at same rate for 2 days.
Intervention: Placebo
Outcomes
Primary Outcomes
Serum lactate
Time Frame: 24 hours postoperative