Cognitive behavioural treatment for persistent positive symptoms in psychotic disorders
Not Applicable
Completed
- Conditions
- Psychotic disorders (schizophrenia, schizophreniform, schizoaffective and delusional disorders)Mental and Behavioural Disorders
- Registration Number
- ISRCTN29242879
- Lead Sponsor
- niversity Hospital Tuebingen (Germany)
- Brief Summary
2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/32041577 secondary analysis (added 12/02/2020) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/33228583/ secondary analysis (added 25/11/2020)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 233
Inclusion Criteria
1. Schizophrenia, schizophreniform, schizoaffective, delusional disorders (according to Diagnostic and Statistical Manual of Mental Disorders - fourth edition [DSM-IV])
2. Score of four or more on the Positive and Negative Syndrome Scale (PANSS)-items ?delusions? or ?hallucinations?
3. Presence of these symptoms for at least three months
Exclusion Criteria
1. Substance abuse or substance dependence as primary clinical problem
2. Organic brain disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary endpoint for efficacy: PANSS positive syndrome (sum of items P1-P7), assessed post treatment (T9).
- Secondary Outcome Measures
Name Time Method <br> Key secondary endpoints:<br> 1. Additional symptom ratings (e.g. PSYRATS)<br> 2. Social functioning<br> 3. Illness related events<br> 4. Quality of life<br> 5. Questionnaires about self schemata and interpersonal schemata<br> 6. Direct and indirect costs<br><br> Assessment of safety:<br> 1. Death<br> 2. Suicidal behaviour<br> 3. Severe depressive symptom exacerbation<br>