Prospective Case Series of Human Uterus Transplantation From Live Donor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- surviving transplants (12 months)
研究概览
简要总结
Uterus transplantation, as a possible future treatment for uterine factor infertility, has been developed in animal species during the last decade.
The study protocol includes transplantation of the uterus from a live donor (mother, relative, friend) into women with absolute uterine factor infertility (lack of uterus from birth or due to life saving hysterectomy).The recipient will be treated by standard immunosuppression and transfer of embryos (acquired by IVF before surgery) will be attempted when at least 12 months have passed from transplantation. Approval for a case series including up to 10 patients has been acquired.
详细描述
The study is ongoing, with inclusion of 9 patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •less than 39 years
- •good general health
排除标准
- •poor ovarian resaerve or older than 39 years
- •systemic or psychiatric disease
结局指标
主要结局
surviving transplants (12 months)
时间窗: up to 3 years after transplantation
次要结局
- pregnancy rate(up to 3 years after transplantation)
研究者
Mats Brännström
Professor
Sahlgrenska University Hospital