Sensori-motor and Perceptual Functions of the Posterior Parietal Cortex (PPC) in Patients With Optic Ataxia (AO) and Healthy Subjects.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 160
- 试验地点
- 2
- 主要终点
- response error - number of pointing error
研究概览
简要总结
To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.
The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.
In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.
Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients and healthy subjects:
- •male and female, age from 18 to 75 years included
- •normal vision or corrected vision
- •covered by social security
- •signed written informed consent
- •neurological injury in posterior parietal cortex supported by a cerebral MRI
- •present optic ataxia symptoms Healthy subjects
- •no known neurological injury
排除标准
- •- unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)
结局指标
主要结局
response error - number of pointing error
时间窗: Day 0 after each stimulation
response error -measure of reaction times
时间窗: Day 0 after each stimulation
response error - percentage of right responses
时间窗: Day 0 after each stimulation
次要结局
未报告次要终点