Sensori-motor and Perceptual Functions of the PPC.

Not Applicable

Recruiting

• Conditions: Optic Ataxia; Healthy Volunteers
• Interventions: Behavioral: point targets; Behavioral: visual images; Behavioral: tactile stimulation

• Registration Number: NCT03286686
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.

The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.

In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.

Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-09-14
• Study First Submitted QC: 2017-09-14
• Study First Posted: 2017-09-18
• Study Start: 2018-02-22
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-29
• Last Update Posted: 2024-01-30
• Primary Completion: 2029-02-22
• Study Completion: 2029-02-22

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

All patients and healthy subjects:

• male and female, age from 18 to 75 years included
• normal vision or corrected vision
• covered by social security
• signed written informed consent

Patients:

• neurological injury in posterior parietal cortex supported by a cerebral MRI
• present optic ataxia symptoms Healthy subjects
• no known neurological injury

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Exclusion Criteria

• unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Experience 1	point targets	-
Experience 2	point targets	-
Experience 4	visual images	-
Experience 5	visual images	-
Experience 3	tactile stimulation	-
Experience 6	visual images	-

Primary Outcome Measures

Name	Time	Method
response error - number of pointing error	Day 0 after each stimulation
response error -measure of reaction times	Day 0 after each stimulation
response error - percentage of right responses	Day 0 after each stimulation

Trial Locations

Locations (1)

U1028 INSERM - CNRS UMR 5292 Equipe ImpAct; 🇫🇷 Bron, France