Microcirculatory Changes During Open Label Magnesium Sulphate Infusion in Severe Sepsis and Septic Shock
Overview
- Phase
- Not Applicable
- Intervention
- Magnesium Sulfate
- Conditions
- Severe Sepsis
- Sponsor
- Medical Centre Leeuwarden
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- microvascular flow index
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.
Detailed Description
In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.
Investigators
Eligibility Criteria
Inclusion Criteria
- •severe sepsis and septic shock
Exclusion Criteria
- •pregnancy
- •oral bleeding
- •age \< 18 years
- •liver cirrhosis
- •acute arrhythmias
- •advanced malignancy or a mean arterial pressure (MAP) \< 65 mmHg refractory to vasopressors
Arms & Interventions
severe sepsis and septic shock
Intervention: Magnesium Sulfate
Outcomes
Primary Outcomes
microvascular flow index
Time Frame: 1 hour
Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.