Evaluation of Adult Onset Still Disease Classification Criteria and Differential Diagnosis at Eighteen Months of Follow-up
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 312
- 主要终点
- diagnosis performance of Yamaguchi and Fautrel criteria at 18 months of follow-up
研究概览
简要总结
Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up of patients. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.
详细描述
Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Other conditions such as cancer, infection or other inflammatory disease might mimick its symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up after an initial diagnosis of AOSD. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 接受健康志愿者
- 否
入选标准
- •with glycosylated ferritin dosage for suspected adult onset still disease
- •with at least 18 month of follow-up
排除标准
- •known infectious disease
- •known cancer
- •known active connective tissue disease or vasculitis
结局指标
主要结局
diagnosis performance of Yamaguchi and Fautrel criteria at 18 months of follow-up
时间窗: after 18 months of follow-up
Sensitivity, Specificity, positive predictive value, negative predictive value
次要结局
- description of differential diagnosis mimicking adult onset still disease(after 18 months of follow-up)
- identifying factors associated with the occurence of a differential diagnosis during follow-up(after 18 months of follow-up)