Exploration of Neuroimaging and Biochemical Prognostic Indicators for POCD

• Conditions: Cognitive Impairment; Postoperative Cognitive Dysfunction

• Registration Number: NCT02164669
• Lead Sponsor: wangqiang

Brief Summary

Postoperative cognitive dysfunction (POCD) may lead to serious consequences. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI and biochemical indicators will be used to explore the underlying mechanisms and represent a promising precursory target for diagnosis and treatment of POCD.

Detailed Description

Postoperative cognitive dysfunction (POCD) is one of the most common complications in patients undergoing cardiac surgery. POCD will not only increase the incidence of complications and mortality, but also influence the quality of life after discharging from the hospital. Many factors are associated with POCD, such as neuroinflammation, age, anesthetics, surgery stress response and genetic factors. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI, which could monitor the peripheral neuron spontaneous activity according to the ratio of oxyhemoglobin and deaeration hemoglobin in blood, will be used to investigate whether POCD is induced by the variance in neurons metabolism and spontaneous activity in brain regions. Meanwhile, biochemical indicators will be detected to explore the prompting indicators of POCD. The present study is aimed to represent a promising precursory target for diagnosis and treatment of POCD, and provide novel evidence and insights on the brain changes induced by POCD.

Study Timeline

• Status Verified: 2013-05
• Study Start: 2013-05
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Study First Submitted: 2014-06-12
• Study First Submitted QC: 2014-06-13
• Last Update Submitted: 2014-06-13
• Study First Posted: 2014-06-16
• Last Update Posted: 2014-06-16

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Aged 18-80 years old
• Underwent selective CABG surgery

Exclusion Criteria

• History of central nervous system or psychiatric disorders
• History of taking sedative, antidepressants, or alcoholism
• MMSE score less than 23
• Visual or auditory disorders
• Educated less than 7 years
• Claustrophobia
• Can not be supine
• Can not tolerate iodinated contrast agents

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The brain structure changes	7 days postoperatively	Using BOLD fMRI to investigate the variance of mean diffusivity and FA in nerve conduction bundle

Secondary Outcome Measures

Name	Time	Method
Mini-Mental State Examination	preoperative and 7 days, 3 months and 1 years postoperative	Application of digital depth and breadth to test digital sign test Tracking the attachment test and assess depression self rating scale

Trial Locations

Locations (1)

Xijign Hospital; 🇨🇳 Xi'an, Shaanxi, China