Can cancer cells be found and counted in blood samples from patients with bone sarcoma?

Not Applicable

• Conditions: Cancer; Sarcoma; Specialty: Cancer, Primary sub-specialty: Sarcoma; UKCRC code/ Disease: Cancer/ Malignant neoplasms of bone and articular cartilage

• Registration Number: ISRCTN29619083
• Lead Sponsor: The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-06-26
• Last Update Posted: 28 March 2022
• Study Completion: 2022-03-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. Patients with a suspected bone sarcoma (any gender and age range 4 to 80 years old)
OR
2. Patients with a confirmed diagnosis of a bone sarcoma (any gender and age range 4 to 80 years old)

Exclusion Criteria

1. Patients (or their parent/guardian for those under the age of 16) who are unable to give informed consent
2. Prisoners
3. Patients who are pregnant

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Enumeration of circulating tumour cells is assessed using flow cytometry at diagnosis, during treatment stages and on completion of treatment to assess for changes in the circulating tumour cell counts.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Correlation of circulating tumour cell number measured by flow cytometry at diagnosis and subsequent treatment stages up to 5 years<br> 2. Genomic analysis is undertaken using next generational sequencing at diagnosis and subsequent treatment stages up to 5 years<br>