NL-OMON55717
Completed
Not Applicable
Pulmonary artERial hypertenSion: bonE morPHOgeNEtic protein signaling out of control (PERSEPHONE) - PERSEPHONE
VU medisch centrum0 sites100 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary arterial hypertension
- Sponsor
- VU medisch centrum
- Enrollment
- 100
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Aim 1: BMP10 secretion by right atrial cardiomyocytes
- •Inclusion criteria patients:
- •\- Patients with chronic thrombo\-embolic pulmonary hypertension (CTEPH)
- •\- Undergoing pulmonary endarterectomy, Inclusion criteria controls:
- •\- Patients undergoing cardiac surgery and put on the heart\-lung machine, Aim 2:
- •BMP10 release as a bio\-assay of right heart failure, Inclusion criteria
- •\- Idiopathic PAH (Invasively assessed mean pulmonary artery pressure \>25 mmHg,
- •pulmonary artery wedge pressure \<15 mmHg)
- •\- Right heart catheterization and magnetic resonance imaging \< 1 year before
- •participation
Exclusion Criteria
- •Aim 1: BMP10 secretion by right atrial cardiomyocytes, Exclusion criteria
- •\- Age \< 18 years, Exclusion criteria controls:
- •\- Pulmonary hypertension (according to European Society of Cardiology
- •guidelines: echocardiography, tricuspid regurgitation peak velocity \* 2\.8
- •m/sec, estimated systolic pulmonary artery pressure \* 36 mmHg and no additional
- •echocardiographic signs of pulmonary hypertension)(13\)
- •\- RV dysfunction (TAPSE \< 16 mm)(13\)
- •\- RV (annulus) dilatation (RV end\-diastolic diameter \> 42 mm (base))(13\)
- •\- Tricuspid valve replacement or tricuspid annuloplasty
- •\- Dilated right atrium or RA dysfunction (e.g. related to atrial fibrillation,
Outcomes
Primary Outcomes
Not specified
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