Pulmonary artERial hypertenSion: bonE morPHOgeNEtic protein signaling out of control (PERSEPHONE) - PERSEPHONE

VU medisch centrum0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Aim 1: BMP10 secretion by right atrial cardiomyocytes
•Inclusion criteria patients:
•- Patients with chronic thrombo-embolic pulmonary hypertension (CTEPH)
•- Undergoing pulmonary endarterectomy, Inclusion criteria controls:
•- Patients undergoing cardiac surgery and put on the heart-lung machine, Aim 2:
•BMP10 release as a bio-assay of right heart failure, Inclusion criteria
•- Idiopathic PAH (Invasively assessed mean pulmonary artery pressure >25 mmHg,
•pulmonary artery wedge pressure <15 mmHg)
•- Right heart catheterization and magnetic resonance imaging < 1 year before
•participation
•- Age > 18 years, Inclusion criteria controls:
•- Age >18 years
•- Age and sex-matched to patients
•- We will include 10 subjects with a BMPR2 mutation without Pulmonary
•Hypertension

•Aim 1: BMP10 secretion by right atrial cardiomyocytes, Exclusion criteria
•- Age < 18 years, Exclusion criteria controls:
•- Pulmonary hypertension (according to European Society of Cardiology
•guidelines: echocardiography, tricuspid regurgitation peak velocity * 2.8
•m/sec, estimated systolic pulmonary artery pressure * 36 mmHg and no additional
•echocardiographic signs of pulmonary hypertension)(13)
•- RV dysfunction (TAPSE < 16 mm)(13)
•- RV (annulus) dilatation (RV end-diastolic diameter > 42 mm (base))(13)
•- Tricuspid valve replacement or tricuspid annuloplasty
•- Dilated right atrium or RA dysfunction (e.g. related to atrial fibrillation,
•congenital abnormalities; cut-off values: area > 18 cm2)
•- Age < 18 years, Aim 2: BMP10 release as a bio-assay of right heart failure,
•Exclusion criteria patients:
•- Pregnancy
•- Claustrophobia
•- Pacemaker, Exclusion criteria controls:
•- Pulmonary hypertension (Invasively assessed mean pulmonary artery pressure >
•- Increased pulmonary artery wedge pressure (>15 mmHg)
•- Tricuspid valve dysfunction
•- RV dysfunction
•- Dilated right atrium or RA dysfunction (e.g. related to atrial fibrillation,
•congenital abnormalities)
•- Previous cardiac surgery
•- Age < 18 years

发起方

VU medisch centrum