The Effect of Stress on the Residual Gastric Volume
- Conditions
- Arthritis Knee
- Interventions
- Dietary Supplement: Carbohydrate drinking
- Registration Number
- NCT05406245
- Lead Sponsor
- Seoul National University Bundang Hospital
- Brief Summary
In our institution, many patients undergo staged bilateral total knee arthroplasty at weekly intervals, and most of the patients are older adults with degenerative arthritis. As recommended, the older adult patients who undergoing total knee arthroplasty drink carbohydrate-containing fluid (400 ml) 2 hours prior to surgery. In this type of surgery, there are additional points to consider when applying the fasting guidelines. This is because, in addition to the factor of advanced age, which can affect gastric emptying time, the patient's physical, medical, and psychological conditions at the first and the second operation may be different. For example, the effect of the acute pain that occurs after the first total knee arthroplasty and subsequent opioids administered on gastric motility cannot be ignored. However, to date, there have been no studies examining the association of stress (emotional and surgical) and residual gastric volume of older adult patients with staged bilateral total knee arthroplasty and whether there is a difference according to the stage when carbohydrate-containing fluid is ingested.
In the present study, the investigators will evaluate the effect of emotional stress, surgical stress, pain, and the use of opioids on the residual gastric volume in older adults undergoing staged-bilateral total knee arthroplasty.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 53
- Patients scheduled for staged bilateral total knee arthroplasty aged ≥ 65
- American Society of Anesthesiologists physical status classification 1, 2, and 3
- Body mass index < 35 kg/cm2
- Patients administered carbohydrate-containing fluid 2 hours prior to surgery
- Previous surgery of the upper gastrointestinal tract
- Achalasia
- Diabetes
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Group C Carbohydrate drinking Patients drank carbohydrate fluid 2 hours prior to surgery.
- Primary Outcome Measures
Name Time Method Level of stress hormone 1 After induction of spinal anesthesia at first stage total knee arthroplasty/ an average 10 minutes Stress hormone (interleukin-1β, interleukin-6, interleukin-10, and tumor necrosis factor-α) measured after induction of spinal anesthesia
Level of stress hormone 2 After induction of spinal anesthesia at second stage total knee arthroplasty/ an average 10 minutes Stress hormone (interleukin-1β, interleukin-6, interleukin-10, and tumor necrosis factor-α) measured after induction of spinal anesthesia
- Secondary Outcome Measures
Name Time Method Gastric volume 1 First stage operation, during the gastric volume measuring at preoperative holding area/ an average of 30 minutes Gastric volume measured before induction of spinal anesthesia using ultrasound
Gastric volume 2 Second stage operation, during the gastric volume measuring at preoperative holding area/ an average of 30 minutes Gastric volume measured before induction of spinal anesthesia using ultrasound
Anxiety scale 2 Second stage operation, one day before surgery/ an average of 30 minutes Anxiety scale measured before surgery
Anxiety scale 1 First stage operation, one day before surgery/ an average of 30 minutes Anxiety scale measured before surgery
Trial Locations
- Locations (1)
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of