Effect of Systemic Ropivacaine on Hyperalgesia, Flare Reaction and Peripheral Nerve Excitability
Phase 4
Completed
- Conditions
- Healthy Volunteers
- Registration Number
- NCT00900913
- Lead Sponsor
- University of Zurich
- Brief Summary
The purpose of this study is to compare the effect of intravenous ropivacaine and lidocaine on the receptive field of primary sensory afferents and their influence on the vascular bed.
\*Trial with medicinal product
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 34
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Aera of flare reaction (cm2), area of primary and secondary hyperalgesia (cm2) 1 year
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie ropivacaine's effect on primary sensory afferents in NCT00900913?
How does systemic ropivacaine compare to lidocaine in modulating peripheral nerve excitability and vascular responses?
Are there specific biomarkers that correlate with reduced hyperalgesia or flare reaction in ropivacaine-treated volunteers?
What adverse events were observed in the University of Zurich's Phase 4 ropivacaine trial and how were they managed?
How do systemic local anesthetics like ropivacaine influence nociceptive pathways compared to other analgesic classes?
Trial Locations
- Locations (1)
Clinical Trial Center
🇨🇭Zurich, Switzerland
Clinical Trial Center🇨🇭Zurich, Switzerland