Dynamic Changes and Surveillance of Circulating Tumor DNA in Surgical Non-small Cell Lung Cancer Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Half-life of circulating tumor DNA after surgery
研究概览
简要总结
Previous study showed circulating tumor DNA levels reflect the total systemic tumor burden. Circulating tumor DNA levels should decrease after complete surgery and could be increase as tumor recurrence. Few study investigated the half time of circulating tumor DNA in lung cancer patients that no criterion has been established of how to use it for surveillance.
详细描述
For lung cancer patients who received surgery, multiple time of plasma will be collected before or after surgery. A series of mutations will be detected in plasma before surgery based on next generation sequencing. The positive mutation will be traced after surgery and in follow up.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspected lung cancer before surgery
- •No malignant tumor history within the past 5 years
- •The pulmonary nodule is not pure ground glass opacity
- •Patients must have given written informed consent
排除标准
- •Multiple primary lung cancer
- •R1,R2 resection
- •Histology confirmed not non-small cell lung cancer
- •Unqualified blood samples
结局指标
主要结局
Half-life of circulating tumor DNA after surgery
时间窗: 3 months
次要结局
- Correlation of circulating tumor DNA level after surgery with clinical features(3 months)
- The variation of circulating tumor DNA level before and after surgery(3 months)
- Correlation of circulating tumor DNA level after surgery with tumor recurrence(3 years)
研究者
Chen KeZhong
Principal Investigator
Peking University People's Hospital