Investigation of the Potentiation of the Analgesic Effects of Fentanyl by Ketamine in Humans: a Double-blinded, Randomised, Placebo Controlled, Crossover Study of Experimental Pai
Completed
- Conditions
- PainSigns and Symptoms
- Registration Number
- ISRCTN83088383
- Lead Sponsor
- Monash Medical Centre (Australia)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Ten healthy male volunteers were recruited via bulletin board advertisements. The volunteers were trained in the test procedures employed and medically screened.
Exclusion Criteria
Volunteers were excluded if they had a history of cardiac, neurological, or musculoskeletal disease. Other exclusion criteria included a history of drug abuse, pain syndromes, myasthenia gravis, acute narrow angle glaucoma, asthma, or heart failure, concurrent use of any analgesics, sedatives, erythromycin, monoamine oxidase (MAO) inhibitors, or allergy to propofol, fentanyl, or ketamine.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain threshold to electrical current, pain threshold to contact heat, pain threshold to pressure, visual analogue scale for sedation, Observer Assessment of Alertness/Sedation Scale (OASS), Symbol Digit Modalities Test (SDMT), auditory reaction time
- Secondary Outcome Measures
Name Time Method ot provided at time of registration