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临床试验/NCT04618887
NCT04618887Unknown不适用

A Comparative Study of GPI's DBS and Pallidotomy in the Treatment of Meige Syndrome

Peking University People's Hospital1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2020年1月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
试验地点
1
主要终点
Symptom

研究概览

简要总结

In this study, we will compare the degree of postoperative symptom improvement, postoperative complication rate, postoperative quality of life improvement degree of patients with Meige syndrome undergoing pallidotomy (unilateral globus palliotomy) and deep brain stimulation (unilateral globus pallidus) ,in order to get the conclusion of the comparison of the clinical efficacy of the two surgical plans. In addition, possible predictive factors such as age, gender, age of onset, length of disease course, scale baseline score, preoperative brain PET-CT function analysis and other possible predictive factors are added for analysis, in order to find predictive factors that can guide the choice of surgical options.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Patients confirmed Meige sydrome

排除标准

  • Patients who cannot finish the neurosurgery or the postoperative evaluation

结局指标

主要结局

Symptom

时间窗: 2 years

spasm of eyelid

complications

时间窗: 2 years

Postoperative complications

次要结局

  • quality of life(2 years)
  • depression scale(2 years)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Liu Ruen

PekingUPH

Peking University People's Hospital

研究点 (1)

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