Prognostic Impact of Anatomical Resection Vs. Non-anatomical Resection for HCC

Not Applicable

• Conditions: Patients Affected by Hepatocellular Carcinoma; Disease-Free Survival; Overall Survival
• Interventions: Procedure: anatomical liver resection; Procedure: Non-anatomical liver resection

• Registration Number: NCT01236989
• Lead Sponsor: University of Milan

Brief Summary

Prognostic impact of AR vs NAR

Detailed Description

Whether anatomical is better than non anatomical resection for HCC is still debated. This prospective randomized study aimed to address which approach is better in terms of patients prognosis.

Study Timeline

• Status Verified: 2010-10
• Study First Submitted: 2010-10-29
• Study First Submitted QC: 2010-11-08
• Last Update Submitted: 2010-11-08
• Study First Posted: 2010-11-09
• Last Update Posted: 2010-11-09
• Study Start: 2011-01
• Primary Completion: 2017-12
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• patient affected by single HCC
• patients in whom liver resection is indicated
• HCC without vascular invasion and/or thrombosis

Exclusion Criteria

• multinodular HCC
• metastatic disease
• spontaneous tumor rupture

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Anatomical resection	anatomical liver resection	-
Non-anatomical resection	Non-anatomical liver resection	-

Primary Outcome Measures

Name	Time	Method
the prognostic impact of anatomical resection by means of intraoperative ultrasound (IOUS) guided vessel compression versus nonanatomical resection in terms of disease free and overall survival	5-years

Secondary Outcome Measures

Name	Time	Method
the impact of anatomical resection versus non-anatomical resection in terms of postoperative mortality and morbility	30 and 90 days

Trial Locations

Locations (1)

IRCCS Istituto Clinico Humanitas; 🇮🇹 Rozzano, Milan, Italy