Influence of Plasma Rich in Growth Factors (PRGF) on Healing of Medial Collateral Ligament (MCL) Tear

Phase 2

Withdrawn

• Conditions: MCL Tear
• Interventions: Drug: saline; Biological: Plasma Rich in Growth Factors (PRGF)

• Registration Number: NCT00743886
• Lead Sponsor: Meir Medical Center

Brief Summary

To evaluate the influence of Plasma Rich in Growth Factors (PRGF) on the healing process of medial collateral ligament (MCL) tear.

Detailed Description

Autologous platelet-rich matrices may aid in the healing of ligaments \& tendons by promoting and accelerating tissue healing because of the release of growth factors including transforming growth factor (TGF)-beta1 and platelet-derived growth factor (PDGF) from platelet alpha-granules.

Study Timeline

• Study Start: 2008-01
• Study First Submitted: 2008-08-28
• Study First Submitted QC: 2008-08-28
• Study First Posted: 2008-08-29
• Primary Completion: 2009-02
• Study Completion: 2009-03
• Status Verified: 2011-07
• Last Update Submitted: 2011-07-10
• Last Update Posted: 2011-07-12

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• age 18-40 years old
• diagnosed MCL tear grade 2/3

Exclusion Criteria

• pregnancy
• mental or physical disabilities

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	saline	saline
1	Plasma Rich in Growth Factors (PRGF)	Plasma Rich in Growth Factors (PRGF)

Primary Outcome Measures

Name	Time	Method
time and efficiency of healing	1 year

Trial Locations

Locations (1)

Meir Medical Center; 🇮🇱 Kfar Saba, Israel