Retrospective Analysis of the Outcome of Patients Diagnosed With Hemophagocytic Lymphohistiocytosis (HLH) Treated at the S.C.Pediatric Oncohematology of the Regina Margherita Torino Hospital (OIRM)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- physiological parameter that are significantly impacting the outcome of patients diagnosed with HLH
研究概览
简要总结
Monocentric, observational, retrospective, no profit study aimed to analyze factors that are significantly impacting the outcome of patients diagnosed with HLH.
详细描述
retrospective data collection to study: type of HLH familial vs secondary, sex, age, presence of infectious cause, involvement central nervous system ( SNC), hepatic involvement, presence of hemophagocytosis, presence of splenomegaly, presence of involvement of other organs, the value of neutrophils (PMN), the value of hemoglobin, platelets, albumin, triglycerides, ferritin, LDH, type of therapy and the response to therapy after 2 months
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Have received HLH diagnosis according to HLH 2004 criteria
- •age ⥶18 years.
- •followed at our facility between January 2004 and December 2021
- •Whose parents have consented to participation and data processing
排除标准
- •The study does not foresee specific exclusion criteria other than the non-compliance with the inclusion criteria
结局指标
主要结局
physiological parameter that are significantly impacting the outcome of patients diagnosed with HLH
时间窗: through study completion, an average of 1 year
Type of HLH (familial vs secondary); sex (M or F); age (in year); presence of infectious cause; involvement central nervous system (yes or no); hepatic involvement (yes or no); presence of hemophagocytosis (yes or no); presence of splenomegaly (yes or no); involvement of other organs (yes or no); value of neutrophils (PMN, in 10\^9/L), hemoglobin (in g/dL), platelets (in 10\^9/L), albumin (in g/L), triglycerides (in mg/dL), ferritin (in UI/L) and LDH (in UI/L);
次要结局
未报告次要终点
研究者
Prof. Franca Fagioli
Clinical Professor
Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna