NCT02005146已完成不适用
Retrospective Observational Study to Define HBsAg Loss With or Without Seroconversion to antiHBs in Patients With Chronic Hepatitis by B Virus Treated With Nucleoside/Nucleotide Analogs
Fundación Pública Andaluza Progreso y Salud22 个研究点 分布在 1 个国家目标入组 86 人开始时间: 2013年12月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 86
- 试验地点
- 22
- 主要终点
- Epidemiological characteristics from hepatitis B patients who lost HBsAg related to treatment with nucleoside/nucleotide analogues
研究概览
简要总结
Define the patients who lost HBsAg, studying the loss predictive factors and if there was suspension of treatment, study the evolution after that
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>18 years old
- •Chronic hepatitis B (HBeAg+ or HBeAg-)
- •HBsAg loss
- •Treated with nucleoside/nucleotide analogues
- •With or without previous interferon (IFN/PEG-IFN)
- •Patients with HBsAg loss after 2006
- •Immunocompetent patients
排除标准
- •Spontaneous HBsAg loss
- •HBsAg loss while treatment in monotherapy or combinated with IFN or PEG-IFN.
- •Patients with hepatitis delta virus (HDV) coinfection.
- •Patients with hepatitis C virus (HCV) coinfection.
- •Patients with HIV coinfection.
- •Patients with liver transplant.
- •Patients with reactivated hepatitis B virus (HBV) by immuno-suppressive treatment.
结局指标
主要结局
Epidemiological characteristics from hepatitis B patients who lost HBsAg related to treatment with nucleoside/nucleotide analogues
时间窗: 15 months
Study the number of diferents virological, serological, clinical, histological, biochemical characteristics from hepatitis B patients who lost HBsAg related to treatment with nucleoside/nucleotide analogues.
次要结局
- Epidemiological characteristics in case of suspension of treatment.(15 months)
研究者
研究点 (22)
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