Is stroke neurodegenerative? A longitudinal study of changes in brain volume and cognition following stroke (CANVAS: Cognition And Neocortical Volume After Stroke)

Austin Health0 sites175 target enrollmentJuly 25, 2016

Overview

No summary available.

Registry

who.int

Start Date

July 25, 2016

End Date

TBD

Last Updated

6 years ago

Study Type

Observational

Sex

All

Sponsor

•Inclusion criteria for the stroke group include:
•1\. Clinical ischaemic stroke;
•2\. Aged greater than 18 years;
•3\. Able to have cognitive testing and MRI scan; and
•4\. Able to give informed consent.
•Inclusion criteria for healthy controls are the same, excluding, of course, the stroke diagnosis.

•Exclusion criteria for stroke patients and control participants are the same. These include:
•1\. Significant medical comorbidities precluding participation in cognitive testing, or making survival for 3 years unlikely;
•2\. Normal exclusion criteria for MRI; e.g., implanted metal, severe claustrophobia;
•3\. Pre\-existing dementia;
•4\. Pregnancy, as a precaution to prevent exposing them to multiple MRI scans in a 12\-month period;
•5\. People in existing dependent or unequal relationships with any member of research team, to protect against coercion.