Chitosan effect on gum disease

Phase 3

Conditions: Chronic periodontitis stage I and II.
Chronic periodontitis
K05.3

Registration Number: IRCT20080914001248N8

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

Have good general health.
At least one tooth with stage1 periodontitis(initial periodontitis) and stage2 periodontitis(moderate periodontitis) that is with a probing depth of =6mm.
This tooth is associated with bleeding on probing(BOP) or gingivitis.

Exclusion Criteria

Tooth with other symptoms such as mobility, furcation lesions, defect of ridge , and bone destruction or probe depth that leads to the difficulty and complexity of the treatment.
Smokers
Pregnant women
Females on hormone therapy
Those who had received systemic or topical antibiotics and/or anti-inflammatory drugs
Those who received surgical or non-surgical periodontal treatment within the past 12 months prior to the enrollment

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bleeding on probing. Timepoint: 14 and 90 days after completion of scaling and application of Chitosan nanoparticle solution. Method of measurement: Bleeding within 30 seconds after periodontal probe insertion Michigan O Williams marking.

Secondary Outcome Measures

Name	Time	Method
Change of probing depth. Timepoint: Baseline, 14 and 90 days after completion of scaling and application of chitosan nanoparticle solution. Method of measurement: periodontal prob of Michigan O With Williams marking.;Clinical attachment level. Timepoint: Baseline, 14 and 90 days after completion of scaling and application of chitosan nanoparticle solution. Method of measurement: periodontal prob of Michigan O With Williams marking.;Gingival recession. Timepoint: Baseline, 14 and 90 days after completion of scaling and application of chitosan nanoparticle solution. Method of measurement: periodontal prob of Michigan O With Williams marking.;Plaque index. Timepoint: Baseline, 14 and 90 days after completion of scaling and application of chitosan nanoparticle solution. Method of measurement: disclosing agents.