Assessment of inflammatory response of bronchial cells to gastric juice from hospitalized infants on and off proton pump inhibitor (PPI) therapy, PICU admitted children and long term users (0-18 years) of PPIs and controls off PPI - Bronchial inflammation to gastric juice from children on and off PPI

Academisch Medisch Centrum0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年4月29日

适应症

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•Group 1 - Hospitalized infants
•- Informed consent signed by care-givers
•- Age ><=34 weeks GA to 6 months
•- Admitted for reasons other than structural gastrointestinal disorders and where no suspicion of such an abnormality exist
•- Tube fed
•- Appointed to be treated with PPIs or no signs of GER related symptoms or aspiration risk and thus unlikely to receive PPI in the near future.;Group 2 - PICU admitted children
•- Informed consent signed by care-givers or patient if aged *12 years
•- Age ><=34 weeks GA to 18 years
•- Admitted for reasons other than structural gastrointestinal disorders and where no suspicion of such an abnormality exist
•- Tube fed
•- Mechanically ventilated
•- Appointed to be treated with PPIs ;Group 3 * outpatient clinic children
•- Informed consent signed by care-givers or patient if aged *12 years
•- Age ><=34 weeks GA to 18 years
•- who have received and currently receive PPI treatment for at least six weeks because of suspected GERD or NO anti-relfux therapy
•- Appointed for intraesophageal evaluation of PPI treatment (eg. pHmetry, endoscopy, manometry) or having a permanent nasogastric/PEG tube

•- > 6 months (Group 1)
•- Prematurity < 34 weeks GA at birth
•- Previous gastro-intestinal (GI) surgery
•- Structural GI abnormalities (exception group 3)
•- Infectious gastro-enteritis
•- Use of medications other than PPIs possibly influencing gastric conditions and/or GI motility
•- Syndromes (exception group 3)

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