NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED

Phase 4

• Conditions: Chronic Renal Failure

• Registration Number: NCT00501475
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The purpose of this study is to evaluate the effect of NAC or sodium bicarbonate in preventing the aggravation of renal function in chronic renal failure when enhanced computed tomography scan is checked in emergency room.

Detailed Description

CIN is frequent in CRF patients. However most studies about CIN has been focusing on elective PCI patients. There is no study that the NAC nor sodium bicarbonate would help in preventing CIN in CRF patients who need enhanced CT scan in ED.

Our intention was to investigate the effect of NAC or sodium bicarbonate in preventing the aggravation of renal function in chronic renal failure when enhanced computed tomography scan is checked in emergency room.

Study Timeline

• Study Start: 2007-03
• Study First Submitted: 2007-07-13
• Study First Submitted QC: 2007-07-13
• Study First Posted: 2007-07-16
• Status Verified: 2010-07
• Last Update Submitted: 2010-07-23
• Last Update Posted: 2010-07-27
• Study Completion: 2010-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• CRF patients who need enhanced CT scan

Exclusion Criteria

• less than 15 years old
• hypersensitivity to NAC
• on dialysis
• no consent from patient or next of kin

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
the rate of CIN	3 days after CT scan

Secondary Outcome Measures

Name	Time	Method
mortality	30 days after CT scan

Trial Locations

Locations (2)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam-si, Gyeongi-do, Korea, Republic of

Seoul National University Hospital; 🇰🇷 Seoul, 28 Yongon-dong, Chongro-gudo, Korea, Republic of