Effect Of Whole Body Vibration Versus Weight Bearing Exercises On Osteoporosis In Breast Cancer Patients After Chemotherapy

Not Applicable

Completed

• Conditions: Breast Cancer; Osteoporosis
• Interventions: Other: Whole body vibration group; Other: Weight bearing exercises; Drug: vitamin D supplements and calcium

• Registration Number: NCT05970250
• Lead Sponsor: Cairo University

Brief Summary

Chemotherapy can damage bone marrow and therefore impair the production of white blood cells, platelets and red blood cells with the resulting anemia and osteoporosis.

Detailed Description

Purposes of this study were:

1. To determine the therapeutic efficacy of the whole-body vibration (WBV) in improving osteoporosis in breast cancer patients after receiving chemotherapy within 3-6 months.

2. To determine the therapeutic efficacy of the weight bearing exercise in improving osteoporosis in breast cancer patients after receiving chemotherapy within 3-6 months.

3. To gain knowledge about the whole-body vibration (WBV) and the weight bearing exercise in improving osteoporosis in breast cancer patients after receiving chemotherapy within 3-6 months.

4. To share in designing an ideal protocol for the treatment of the osteoporosis in breast cancer patients after receiving chemotherapy within 3-6 months.

Study Timeline

• Study Start: 2022-01-20
• Primary Completion: 2022-04-20
• Study Completion: 2022-07-20
• Status Verified: 2023-07
• Study First Submitted: 2023-07-24
• Study First Submitted QC: 2023-07-24
• Last Update Submitted: 2023-07-24
• Study First Posted: 2023-08-01
• Last Update Posted: 2023-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis.
• Their age ranges from 35-55 years old.
• All patients will have the same medical and nursing care.
• All the patients will receive a good explanation of treatment and measurement device.
• They are neurologically free.

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Exclusion Criteria

Patients will be excluded from this study for any of the following causes:

• Uncooperative patients.
• Instability of patient's medical condition.
• Association of another medical problem.
• Patients who have diabetes.
• Patients who have history of medical chronic relevant diseases.
• Patients who have acute or chronic hepatitis.
• Patients who have pacemaker.
• Patients who have genitourinary infections.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Weight bearing exercises group	vitamin D supplements and calcium	In this group (the second study group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received aerobic exercise on treadmill as form of weight bearing exercise 20 minutes 3 times per week for 2 months and drug therapy (vitamin D supplements and calcium).
Whole body vibration group	Whole body vibration group	In this group (the first study group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received the whole body vibration, 20 minutes 3 times per week for 2 months and drug therapy (vitamin D supplements and calcium).
Whole body vibration group	vitamin D supplements and calcium	In this group (the first study group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received the whole body vibration, 20 minutes 3 times per week for 2 months and drug therapy (vitamin D supplements and calcium).
Weight bearing exercises group	Weight bearing exercises	In this group (the second study group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received aerobic exercise on treadmill as form of weight bearing exercise 20 minutes 3 times per week for 2 months and drug therapy (vitamin D supplements and calcium).
drug therapy group	vitamin D supplements and calcium	In this group (control group) fifteen breast cancer patients after receiving chemotherapy within 3-6 months and complaining from osteoporosis were received only drug therapy (vitamin D supplements and calcium. Measurements were conducted before starting the treatment as a first record, at end of the second month of treatment as second record and make follow up after 3 months as final record.

Primary Outcome Measures

Name	Time	Method
Assessing the change in bone mineral density	at baseline and after 2 months of intervention	By using DEXA (dual-energy X-ray absorptiometry): Dual-energy X-ray absorptiometry (DEXA) is a clinically proven method of measuring bone mineral density (BMD) in the lumbar spine, proximal femur, forearm, and whole body. It is used primarily in the diagnosis and management of osteoporosis and other disease states characterized by abnormal BMD, as well as to monitor response to therapy for these conditions .

Trial Locations

Locations (1)

Outpatient clinic faculty of physical therapy cairo university; 🇪🇬 Dokki, Egypt