NCT01450059已完成不适用
Maternal-fetal CD4 Microchimerism in HiV Exposed Newborns After Spontaneous Delivery and Cesarean Section
Johann Wolfgang Goethe University Hospital1 个研究点 分布在 1 个国家目标入组 54 人开始时间: 2011年8月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Maternal CD4+ t-cells in HiV exposed Newborns
研究概览
简要总结
The aim of this single centre study is to measure maternal CD4+ t-cells in HiV exposed Newborns after spontaneous birth in comparison to cesarean section.
This may have an influence on the risk of vertical HiV transmission.
详细描述
At birth maternal CD4+ t-cells from umbilical cord blood and placenta blood are measured by microchimerism-analysis.
After 6 weeks the maternal CD4+ t-cells are measured in the blood of the babies blood.
Additionally we look for HiV in maternal CD4+ t-cells.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Minute 至 10 Minutes（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HiV exposed Newborns with normal risk of HiV transmission.
排除标准
- •HiV exposed Newborns wiht elevated or high risk of HiV transmission.
- •HiV exposed Newborns of mothers not full of age.
- •missing informed consent of at least the mother
- •Major congenital defects
- •Chromosomal anomalies
结局指标
主要结局
Maternal CD4+ t-cells in HiV exposed Newborns
时间窗: Six weeks after date of birth
The maternal CD4+ t-cells are measured by microchimersimanalysis
次要结局
- HiV transmission rate(6 month after birth)
- Analysis of HiV in maternal CD4+ t-cells(2 month after delivery)
- Measurement of maternal CD8+ t-cells in the Newborn(6 weeks)
研究者
Dr. med. Horst Buxmann
Principal Investigator
Johann Wolfgang Goethe University Hospital
研究点 (1)
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