Precision medicine for patients with RAS wild metastatic colorectal cancer by using liquid biopsy

Not Applicable

Recruiting

• Conditions: metastatic colorectal cancer

• Registration Number: JPRN-UMIN000031177
• Lead Sponsor: ippon Medical School

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

1)contraindications for EGFR blockades 2)previously received chemotherapy with EGFR blockades 3)severe drug allergy 4)pregnant woman or Possibility of the pregnant woman. male patient who hoping partner's pregnancy. 5)patient who has important clinical complications(symptomatic unstable ischemic heart disease, arrhythmia, acute myocardial infarction within 6 months, liver cirrhosis, renal failure, active gastrointestinal ulcer, ileus, uncontrolled diabetes, uncontrolled hypertension, etc.) 6)other active malignancies 7)have pleural effusion and ascitic fluid with the treatment 8)Comorbidity or history of heart failure 9)Clinical or radiological evidence of CNS metastases 10)Synchronous or metachronous multiple malignancy within the last 5 year disease free interval 11)Under continuous steroid administration 12)decision of unsuitable for this study by the investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Response rate

Secondary Outcome Measures

Name	Time	Method
The rate of Early tumor shrinkage Progression free survival Overall survival