Effects of Prebiotics on GLP-1 in Type 2 Diabetes
- Conditions
- Diabetes Type 2
- Interventions
- Dietary Supplement: Maltodextrin
- Registration Number
- NCT02569684
- Lead Sponsor
- Oslo University Hospital
- Brief Summary
The aim of the study is to compare the effects of prebiotics versus placebo on blood concentrations of glucagon-like peptide-1 in subjects with diabetes type 2.
- Detailed Description
We looked at 6 weeks supplementation with a prebiotic fibre mix of inulin and FOS. Cross over design compared to maltodextrin as placebo. Additional outcome measures: blood glucose, insulin, GLP-2, ghrelin, PYY and leptin after a standardized mixed meal test. Also measured changes in microbiota composition and SCFA in feces before and after intervention/placebo periods, and subjective measures of appetite.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 37
- diabetes type 2
- BMI 18,5 - 40
- Not medicated with insulin, GLP-1 analogues or DPP4 inhibitors
- Moderate intake of alcohol
- Not excessive exercise
- Less than 3 kg weight change the last two months
- Intake of less than 30 g dietary fiber per day
- IBD
- IBS
- Coeliac disease
- Have used antibiotics within the last two months
- Have used supplements with prebiotics or probiotics the last two months
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Arm B Maltodextrin Maltodextrin
- Primary Outcome Measures
Name Time Method Changes in plasma GLP-1 in response to standardized test meal before and after six weeks of ingestion of prebiotic fibers or placebo six weeks The changes in GLP-1 response to either prebiotic fibers or placebo will be compared in a cross-over manner where the participants are their own controls. In between the intervention periods there will be a wash-out period of 4 weeks.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oslo University Hospital
🇳🇴Oslo, Norway