Hemodynamic Effect of Dexmedetomidine on Heavy Bupivacaine Spinal Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Incidence of Hypotension
研究概览
简要总结
Patients were randomized into two groups, A group and B group. A group and B group patients are injected intravenous dexmedetomidine after intrathecal injection (IT) of heavy bupivacaine and injected intravenous dexmedetomidine before IT of heavy bupivacaine, respectively.
The investigators will compare of hemodynamics and patient's comfortability between two groups.
详细描述
A and B group patients will intravenous inject dexmedetomidine 1mcg/kg for 10 minute loading infusion and 0.2mcg/kg/hr for continuous infusion. A group receive intravenous dexmedetomidine after procedure, and B group receive intravenous dexmedetomidine before procedure. Both group patients will hydrate 6 ml/kg crystalloid solution and will evaluated patient's anxiety and comfortability perioperative period. Vital signs will record 5 minutes interval at operating room and post-anesthetic care units.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •20 - 60 aged patients
- •orthopedic operation undergoing spinal anesthesia
排除标准
- •more than American society of anesthesiologists classification 3
- •hypertension
- •diabetes mellitus
- •heart disease (bradycardia, atrioventricular block)
研究组 & 干预措施
Dexmedetomidine
IV dexmedetomidine infusion before intrathecal injection of heavy bupivacaine
干预措施: Dexmedetomidine (Drug)
Dexmedetomidine with heavy bupivacaine
IV dexmedetomidine infusion after intrathecal injection of heavy bupivacaine
干预措施: Dexmedetomidine with heavy bupivacaine (Drug)
结局指标
主要结局
Incidence of Hypotension
时间窗: up to 3 hours
We compare incidence rate of hypotension during infusion of dexmedetomidine
次要结局
- Patient's Anxiety(up to 3 days)
研究者
Ki Hwa Lee
Assistant professor
Inje University