Visual Outcome Evaluation and Genetic Analysis: Shanghai Pediatric Cataract Study

Evidence Based Cataract Study Group1 site in 1 country10,000 target enrollmentJanuary 1, 2009

ConditionsPediatric Cataract Congenital Cataract Traumatic Cataract Visual Outcome Genetic Anticipation

Overview

Phase: N/A
Intervention: Not specified
Conditions: Pediatric Cataract
Sponsor: Evidence Based Cataract Study Group
Enrollment: 10000
Locations: 1
Primary Endpoint: Differences in the visual outcomes of pediatric cataract patients.
Status: Recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.

Registry

clinicaltrials.gov

Start Date

January 1, 2009

End Date

December 31, 2045

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Evidence Based Cataract Study Group

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Clinical diagnosis of pediatric cataract
•Must be able to cooperate with the ophthalmic examination

Exclusion Criteria

•Clinical diagnosis of mental illness
•Mentally disabled

Outcomes

Primary Outcomes

Differences in the visual outcomes of pediatric cataract patients.

Time Frame: Follow-up until ten years after surgery.

Visual outcomes are evaluated including visual acuity with or without correction, refractive changes, intraocular pressure, fundus function, fixation type, vision development, growth of axial length, contrast sensitivity and other visual outcome measurements.

Genetic diversity based on biospecimen samples of pediatric cataract patients.

Time Frame: Analyzed within six months after surgery.

Sequencing of genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of congenital cataract patients, compared to traumatic cataract patients.Samples of blood, aqueous humor, anterior capsular membranes and lens tissues were applied for the genetic analysis.