The retrospective study of treatment by thrombomodulin for acute exacerbations of idiopathic pulmonary fibrosis, acute respiratory distress sydmrome
Not Applicable
Recruiting
- Conditions
- acute exacerbations of idiopathic pulmonary fibrosis, acute respiratory distress syndrome
- Registration Number
- JPRN-UMIN000012590
- Lead Sponsor
- Chiba University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
The AE-IPF-patients were excluded if they had obvious signs of infection, preexisting pulmonary embolisms, left heart failure, pulmonary hypertension due to pulmonary thromboemboli or phlebitis based on the findings of color Doppler ultrasonography or enhanced HRCT. Patient or family refusal for invasive mechanical ventilation was an exclusionary criterion for endotracheal intubation. Such patients were excluded from this study.
Study & Design
- Study Type
- Interventional,observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The outcomes of patients included the 28-day mortality and in-hospital mortality after beginning treatment with rhTM were compared with those of untreated patients.
- Secondary Outcome Measures
Name Time Method We investigated whether or not they showed any improvement in oxygenation (SpO2/FIO2) and intravascular coagulation disturbance (TAT, FDP) in the acute phase.