Studying the effect of air pollutants on health

Not Applicable

• Conditions: This is a study of healthy volunteers aged 50 years or above who have a close relative with dementia; Not Applicable

• Registration Number: ISRCTN85634746
• Lead Sponsor: niversity of Manchester

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-03-20
• Last Update Posted: 17 April 2023
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

1. Aged =50 years old
2. Family history of dementia
3. Provision of signed, written and dated informed consent, prior to any study-specific procedures

Exclusion Criteria

1. Neurological or psychiatric disorder
2. General Practitioner Assessment of Cognition Score of =7
3. Current smoker (including e-cigarettes) or ex-smoker of less than 6 months abstinence, and >20 pack-year history
4. Current pregnancy
5. Significantly abnormal spirometry
6. History of cardiac disease
7. History of chronic respiratory or airways disease
8. History of inflammatory diseases (e.g. rheumatoid arthritis, chronic periodontitis, inflammatory bowel disease)
9. History of neurological or psychiatric disorders
10. History of organ transplant
11. Consumption of >3 units of alcohol in the 24 hours preceding the testing visit
12. Any vaccination in the week prior to the testing visit
13. Cold or flu in the 48 hours prior to the testing visit
14. Visual impairment not correctable with glasses/contact lenses.
15. Significant claustrophobia preventing the participant from wearing a mask over the nose and mouth for an hour
16. Concomitant medication use of neurologically active drugs such as opiates/benzodiazepines/anti-epileptics etc
17. Substance misuse

Study & Design

• Study Type: Observational
• Study Design: Not specified