Refractory Status Epilepticus Treatment: Quality and Efficacy of Coma Induction

Completed

• Conditions: Status Epilepticus; Refractory Status Epilepticus

• Registration Number: NCT04333082
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

This study is to investigate the effects of different treatment characteristics regarding the use of intravenous anesthetic drugs (IVADs) as a rescue treatment for refractory Status epilepticus (RSE) on course and outcome. A retrospective data extraction from the digital medical records, the electroencephalographic and microbiologic database of all consecutive adult patients with Status epilepticus (SE) admitted to the University Hospital Basel is undertaken.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-03-31
• Study First Submitted QC: 2020-03-31
• Study First Posted: 2020-04-03
• Study Start: 2020-04-22
• Primary Completion: 2021-08-15
• Study Completion: 2022-08-03
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-22
• Last Update Posted: 2024-02-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 147

Inclusion Criteria

• diagnosed SE between 2005 and 2019 who have been treated at intensive care units (ICUs) of the University Hospital of Basel

Exclusion Criteria

• Patients with repetitive epileptic seizures not qualifying for SE or RSE
• Patients with documented refusal of the general in-house consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
number of in- hospital death	at baseline (T0)	number of in- hospital death

Secondary Outcome Measures

Name	Time	Method
neurofunctional alteration assessed by Glasgow Outcome Score (GOS)	at baseline (T0)	neurofunctional alteration assessed by Glasgow Outcome Score (GOS). The Glasgow Outcome Scale (GOS) is a global scale for functional outcome that rates patient status into one of five categories: Dead, Vegetative State, Severe Disability, Moderate Disability or Good Recovery

Trial Locations

Locations (1)

Clinic for Intensive Care Medicine, University Hospital Basel; 🇨🇭 Basel, Switzerland