A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

Phase 3

Recruiting

• Conditions: Ulcerative Colitis
• Interventions: Drug: Mirikizumab

• Registration Number: NCT03519945
• Lead Sponsor: Eli Lilly and Company

Brief Summary

This study is designed to evaluate the long-term efficacy and safety of mirikizumab in participants with moderately to severely active ulcerative colitis (UC). The study will last up to 3 years. Participants who complete the 3-year study may continue to receive mirikizumab until it is (outside of this study) in their country or until they meet other discontinuation criteria.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-05-07
• Study First Submitted QC: 2018-05-07
• Study First Posted: 2018-05-09
• Study Start: 2018-07-18
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-26
• Last Update Posted: 2024-12-27
• Primary Completion: 2026-07
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1063

Inclusion Criteria

Not provided

Read More

Exclusion Criteria

Not provided

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Mirikizumab	Mirikizumab	Mirikizumab administered subcutaneously (SC).

Primary Outcome Measures

Name	Time	Method
Percentage of Participants in Clinical Remission	Week 52	Clinical remission based on the modified Mayo Score (MMS).

Secondary Outcome Measures

Name	Time	Method
Percentage of Participants in Endoscopic Remission	Week 52	Endoscopic remission based on the MMS Endoscopic Subscore (ES).
Percentage of Participants in Corticosteroid-free Remission	Week 52	Participants in corticosteroid-free remission.
Health Related Quality of Life: Inflammatory Bowel Disease Questionnaire (IBDQ) Score	Baseline to Week 52	Health Related Quality of Life based on IBDQ score.
Percentage of Participants with Histologic-Endoscopic Mucosal Remission at Week 52	Week 52	Endoscopic remission based on the MMS ES and histologic remission based on histologic disease activity index.
UC Symptoms: Numeric Rating Score	Week 160	UC symptoms based on numeric rating score.
Percentage of Participants Who are Hospitalized Due to UC	Baseline to Week 160	Participants who are hospitalized due to UC.
Percentage of Participants Who Undergo UC Surgeries Including Colectomy	Baseline to Week 160	Participants who undergo UC surgeries including colectomy.

Trial Locations

Locations (364)

Ospedale San Martino; 🇮🇹 Genova, Italy

Ospedale Mauriziano; 🇮🇹 Torino, Italy

National Hospital Organization Hirosaki National Hospital; 🇯🇵 Hirosaki, Aomori, Japan

Toho University Sakura Medical Center; 🇯🇵 Sakura, Chiba, Japan

Kitakyushu Municipal Medical Center; 🇯🇵 Kitakyusyu-shi, Fukoka, Japan

Hidaka Coloproctology Clinic; 🇯🇵 Kurume-shi, Fukuoka-Ken, Japan

Gunma University Hospital; 🇯🇵 Maebashi, Gunma, Japan

National Hospital Organization Takasaki General Medical Centar; 🇯🇵 Takasaki, Gunma, Japan

Digestive Health Specialists; 🇺🇸 Dothan, Alabama, United States

Research Solutions of Arizona; 🇺🇸 Litchfield Park, Arizona, United States

Valleywise Health Medical Center; 🇺🇸 Phoenix, Arizona, United States

InSite Digestive Health Care; 🇺🇸 Arcadia, California, United States

Care Access - Berkeley; 🇺🇸 Berkeley, California, United States

University of California San Diego; 🇺🇸 La Jolla, California, United States

Om Research LLC; 🇺🇸 Lancaster, California, United States

California Medical Research Associates; 🇺🇸 Northridge, California, United States

Inland Empire Clinical Trials, LLC; 🇺🇸 Rialto, California, United States

Clinical Applications Laboratories, Inc.; 🇺🇸 San Diego, California, United States

Direct Helpers Research Center; 🇺🇸 Hialeah, Florida, United States

Encore Borland-Groover Clinical Research; 🇺🇸 Jacksonville, Florida, United States

Wellness Clinical Research; 🇺🇸 Miami Lakes, Florida, United States

Research Associates of South Florida; 🇺🇸 Miami, Florida, United States

AdventHealth Orlando; 🇺🇸 Orlando, Florida, United States

Clintheory Healthcare; 🇺🇸 Orlando, Florida, United States

Gastroenterology Associates of Pensacola, PA; 🇺🇸 Pensacola, Florida, United States

Florida Medical Clinic LLC; 🇺🇸 Zephyrhills, Florida, United States

Digestive Healthcare of Georgia; 🇺🇸 Atlanta, Georgia, United States

Grand Teton Research Group; 🇺🇸 Idaho Falls, Idaho, United States

NorthShore University HealthSystem - Evanston Hospital; 🇺🇸 Evanston, Illinois, United States

Indiana University Health University Hospital; 🇺🇸 Indianapolis, Indiana, United States

Cotton O'Neil Digestive Health Center; 🇺🇸 Topeka, Kansas, United States

GI Alliance Research Baton Rouge; 🇺🇸 Baton Rouge, Louisiana, United States

Delta Research Partners; 🇺🇸 Monroe, Louisiana, United States

Nola Research Works, LLC; 🇺🇸 New Orleans, Louisiana, United States

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

Clinical Research Institute of Michigan, LLC; 🇺🇸 Chesterfield, Michigan, United States

Henry Ford Medical Center - Columbus Center; 🇺🇸 Novi, Michigan, United States

West Michigan Clinical Research Center; 🇺🇸 Wyoming, Michigan, United States

MNGI Digestive Health - Plymouth Endoscopy Center & Clinic; 🇺🇸 Plymouth, Minnesota, United States

NYU Langone Long Island Clinical Research Associates; 🇺🇸 Great Neck, New York, United States

Columbia University Medical Center; 🇺🇸 New York, New York, United States

Clinical & Translational Research Center (CTRC); 🇺🇸 Chapel Hill, North Carolina, United States

Carolina Digestive Diseases and Endoscopy Center; 🇺🇸 Greenville, North Carolina, United States

Care Access - Youngstown; 🇺🇸 Poland, Ohio, United States

The University of Oklahoma Health Sciences Center; 🇺🇸 Oklahoma City, Oklahoma, United States

Central Sooner Research - Oklahoma - Northwest 47th Street; 🇺🇸 Oklahoma City, Oklahoma, United States

Care Access - Pottsville; 🇺🇸 Pottsville, Pennsylvania, United States

Azienda Ospedaliera Mater Domini; 🇮🇹 Catanzaro, Italy

Digestive Disease Associates; 🇺🇸 Wyomissing, Pennsylvania, United States

Midwest Medical Care; 🇺🇸 Sioux Falls, South Dakota, United States

GI Alliance; 🇺🇸 Southlake, Texas, United States

Baylor College of Medicine; 🇺🇸 Houston, Texas, United States

Biopharma Informatic, LLC; 🇺🇸 Houston, Texas, United States

Gastroenterology Research of San Antonio; 🇺🇸 San Antonio, Texas, United States

Southern Star Research Institute; 🇺🇸 San Antonio, Texas, United States

Texas Digestive Disease Consultants; 🇺🇸 Southlake, Texas, United States

Care Access-Ogden; 🇺🇸 Ogden, Utah, United States

Care Access Research LLC - Salt Lake City; 🇺🇸 Salt Lake City, Utah, United States

Carilion Clinic; 🇺🇸 Roanoke, Virginia, United States

Washington Gastroenterology - Tacoma; 🇺🇸 Tacoma, Washington, United States

Mautalen Salud e Investigación; 🇦🇷 Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina

CER medical Institute; 🇦🇷 Quilmes, Ciudad Autónoma De Buenos Aires, Argentina

Fundacion Estudios Clinicos; 🇦🇷 Rosario, Santa Fe, Argentina

Centro de Investigaciones Médicas Tucuman; 🇦🇷 SAN M. DE Tucuman, Tucumán, Argentina

C.I.C.E. 9 de Julio; 🇦🇷 San Miguel de Tucumán, Tucumán, Argentina

Mater Misericordiae Limited; 🇦🇺 Brisbane, Queensland, Australia

Princess Alexandra Hospital; 🇦🇺 Brisbane, Queensland, Australia

Coastal Digestive Health; 🇦🇺 Maroochydore, Queensland, Australia

Royal Adelaide Hospital; 🇦🇺 Adelaide, South Australia, Australia

Box Hill Hospital; 🇦🇺 Box Hill, Victoria, Australia

St Vincent's Hospital; 🇦🇺 Melbourne, Victoria, Australia

The Royal Melbourne Hospital; 🇦🇺 Parkville, Victoria, Australia

Medizinische Universitaet Innsbruck; 🇦🇹 Innsbruck, Tirol, Austria

Universitaetsklinikum Allgemeines Krankenhaus Wien; 🇦🇹 Vienna, Wien, Austria

Uniklinikum Salzburg; 🇦🇹 Salzburg, Austria

UZ Gent; 🇧🇪 Gent, Oost-Vlaanderen, Belgium

UZ Leuven; 🇧🇪 Leuven, Vlaams-Brabant, Belgium

Centre Hospitalier de Wallonie Picarde - Site Notre Dame; 🇧🇪 Tournai, Wallonne, Région, Belgium

Fraser Clinical Trials Inc; 🇨🇦 New Westminster, British Columbia, Canada

Vancouver General Hospital; 🇨🇦 Vancouver, British Columbia, Canada

GIRI GI Research Institute - Vancouver; 🇨🇦 Vancouver, British Columbia, Canada

PerCuro Clinical Research; 🇨🇦 Victoria, British Columbia, Canada

Victoria Hospital; 🇨🇦 London, Ontario, Canada

University Hospital - London Health Sciences Centre; 🇨🇦 London, Ontario, Canada

CISSS de la Monteregie-Centre; 🇨🇦 Greenfield Park, Quebec, Canada

CIUSSS de l'Est-de-l'Île-de-Montréal; 🇨🇦 Montreal, Quebec, Canada

Montreal General Hospital; 🇨🇦 Montreal, Quebec, Canada

The First Affiliated Hospital of Anhui Medical University; 🇨🇳 Hefei, Anhui, China

Anhui Provincial Hospital; 🇨🇳 Hefei, Anhui, China

The Sixth Affiliated Hospital of Sun Yat-sen University; 🇨🇳 Guangzhou, Guangdong, China

Hainan General Hospital; 🇨🇳 Haikou, Hainan, China

The Second Afilliated Hospital of Hebei Medical University; 🇨🇳 Shijiazhuang, Hebei, China

The Second Affiliated Hospital of Zhengzhou University; 🇨🇳 Zhengzhou Shi, Henan, China

Wuhan Union Hospital; 🇨🇳 Wuhan, Hubei, China

Tongji Hospital Tongji Medical,Science & Technology; 🇨🇳 Wuhan, Hubei, China

Renmin Hospital of Wuhan University; 🇨🇳 Wuhan, Hubei, China

Xiangya Hospital Central South University; 🇨🇳 Changsha, Hunan, China

ZhuZhou Central Hospital; 🇨🇳 Zhuzhou, Hunan, China

Changzhou No.2 People's Hospital; 🇨🇳 Changzhou, Jiangsu, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School; 🇨🇳 Nanjing, Jiangsu, China

Zhongda Hospital Southeast University; 🇨🇳 Nanjing, Jiangsu, China

Jiangsu Province Hospital; 🇨🇳 Nanjing, Jiangsu, China

Nanjing Medical University - Nanjing Jiangning Hospital; 🇨🇳 Nanjing, Jiangsu, China

The First Affiliated Hospital of Nanchang University; 🇨🇳 Nanchang, Jiangxi, China

Jiangxi Pingxiang People's Hospital; 🇨🇳 Pingxiang, Jiangxi, China

Center-Jilin Center Hospital; 🇨🇳 Jilin, Jilin, China

Shengjing Hospital of China Medical University; 🇨🇳 Shenyang, Liaoning, China

Shandong Provincial Hospital; 🇨🇳 Jinan, Shandong, China

Qilu Hospital of Shandong University; 🇨🇳 Jinan, Shandong, China

The Affiliated Hospital of Qingdao University; 🇨🇳 Qingdao, Shandong, China

Taian City Central Hospital; 🇨🇳 Taian, Shandong, China

Renji Hospital Shanghai Jiao Tong University School of Medicine; 🇨🇳 Shanghai, Shanghai, China

Shanghai Jiaotong University School of Medicine Ruijin Hospital; 🇨🇳 Shanghai, Shanghai, China

West China Hospital of Sichuan University; 🇨🇳 Cheng Du, Sichuan, China

First Affiliated Hospital of Kunming Medical University; 🇨🇳 Kunming, Yunnan, China

The First People's Hospital of Yunnan Province; 🇨🇳 Kunming, Yunnan, China

The First Affiliated Hospital, Zhejiang University; 🇨🇳 Hangzhou, Zhejiang, China

Sir Run Run Shaw Hospital; 🇨🇳 Hangzhou, Zhejiang, China

The Second Affiliated hospital of Zhejiang University school of medicine; 🇨🇳 Hangzhou, Zhejiang, China

The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University; 🇨🇳 Wenzhou, Zhejiang, China

The First Affiliated Hospital Of Fujian Medical University; 🇨🇳 Fuzhou, China

Liaocheng People's Hospital; 🇨🇳 Liaocheng, China

Vojenská Nemocnice Brno; 🇨🇿 Brno, Brno-město, Czechia

Fakultni Nemocnice u sv. Anny v Brne; 🇨🇿 Brno, Brno-město, Czechia

Hepato-Gastroenterologie HK; 🇨🇿 Hradec Kralove, Hradec Králové, Czechia

MUDr. Gregar, s.r.o.; 🇨🇿 Olomouc, Olomoucký Kraj, Czechia

A-Shine; 🇨🇿 Pilsen, Plzeň-město, Czechia

PreventaMed; 🇨🇿 Olomouc, Czechia

Fakultni nemocnice Kralovske Vinohrady; 🇨🇿 Praha 10, Czechia

MEDIENDO; 🇨🇿 Praha 8, Czechia

ISCARE klinicke centrum; 🇨🇿 Praha 9, Czechia

Herlev and Gentofte Hospital; 🇩🇰 Copenhagen, Hovedstaden, Denmark

Sjællands Universitetshospital Køge; 🇩🇰 Køge, Sjælland, Denmark

Sygehusenheden Nyborg; 🇩🇰 Nyborg, Syddanmark, Denmark

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet; 🇫🇷 Nice, Alpes-Maritimes, France

Nouvel Hôpital Civil (NHC); 🇫🇷 Strasbourg, Alsace, France

CHU Bordeaux Haut-Leveque; 🇫🇷 Pessac, Aquitaine, France

CHRU Troussau; 🇫🇷 Chambray Les Tours, Centre, France

Centres Médico Chirurgicaux - Clinique Ambroise Paré; 🇫🇷 Neuilly-sur-Seine, Hauts-de-Seine, France

Chu Saint Eloi; 🇫🇷 Montpellier, Languedoc-Roussillon, France

Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord; 🇫🇷 Saint Priest En Jarez, Loire, France

Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois; 🇫🇷 Vandoeuvre lès Nancy, Lorraine, France

Hopital Claude Huriez - CHU de Lille; 🇫🇷 Lille, Nord, France

Centre Hospitalier de Pau; 🇫🇷 Pau, Pyrénées-Atlantiques, France

Centre Hospitalier Lyon Sud; 🇫🇷 Pierre-Bénite, Rhône, France

CHU d'Amiens-Picardie - Hôpital Sud; 🇫🇷 Amiens, Somme, France

Hôpital Saint-Louis; 🇫🇷 Paris, France

LLC ARENSIA Exploratory Medicine; 🇬🇪 Tbilisi, Georgia

Medizinische Hochschule Hannover; 🇩🇪 Hannover, Niedersachsen, Germany

Haus der Gesundheit; 🇩🇪 Ludwigshafen, Rheinland-Pfalz, Germany

Studiengesellschaft BSF Unternehmergesellschaft; 🇩🇪 Halle (Saale), Sachsen-Anhalt, Germany

Universitätsklinikum Halle; 🇩🇪 Halle, Sachsen-Anhalt, Germany

Charite Universitätsmedizin Berlin Campus Benjamin Franklin; 🇩🇪 Berlin, Germany

Krankenhaus Waldfriede; 🇩🇪 Berlin, Germany

Städtisches Klinikum Brandenburg; 🇩🇪 Brandenburg, Germany

HaFCED e.K. - Hamburgisches Forschungsinstitut für chronisch entzündliche Darmerkrankungen; 🇩🇪 Hamburg, Germany

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ; 🇭🇺 Szeged, Csongrád, Hungary

Petz Aladar Egyetemi Oktato Korhaz; 🇭🇺 Győr, Győr-Moson-Sopron, Hungary

Jávorszky Ödön Kórház; 🇭🇺 Vác, Pest, Hungary

CLINFAN Szolgáltató Kft; 🇭🇺 Szekszárd, Tolna, Hungary

Óbudai Egészségügyi Centrum; 🇭🇺 Budapest, Hungary

Semmelweis University; 🇭🇺 Budapest, Hungary

Eszak-budai Szent Janos Centrumkorhaz; 🇭🇺 Budapest, Hungary

Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház; 🇭🇺 Békéscsaba, Hungary

Endomedix Diagnosztikai Központ - Miskolc; 🇭🇺 Miskolc, Hungary

Apollo Hospitals Ahmedabad; 🇮🇳 Ahmedabad, Gujarat, India

Shree Giriraj Multispeciality Hospital; 🇮🇳 Rajkot, Gujarat, India

Nirmal Hospital; 🇮🇳 Surat, Gujarat, India

M S Ramaiah Medical College and Hospitals; 🇮🇳 Bangalore, Karnataka, India

Midas Multispeciality Hospital Pvt.Ltd.; 🇮🇳 Nagpur, Maharashtra, India

Grant Medical Foundation - Ruby Hall Clinic; 🇮🇳 Pune, Maharashtra, India

Acharya Vinoba Bhave Rural Hospital; 🇮🇳 Wardha, Maharashtra, India

Dayanand Medical College and Hospital; 🇮🇳 Ludhiana, Punjab, India

SR Kalla Memorial Gastro & General Hospital; 🇮🇳 Jaipur, Rajasthan, India

Owaisi Hospital and Research Center; 🇮🇳 Hyderabad, Telangana, India

Gandhi Hospital; 🇮🇳 Secunderabad, Telangana, India

Fortis Hospital; 🇮🇳 Noida, Uttar Pradesh, India

Beaumont Hospital, Dublin; 🇮🇪 Dublin, Ireland

Soroka Medical Center; 🇮🇱 Be'er Sheva, HaDarom, Israel

Kaplan Medical Center; 🇮🇱 Rehovot, HaMerkaz, Israel

Yitzhak Shamir Medical Center; 🇮🇱 Zerifin, HaMerkaz, Israel

Galilee Medical Center; 🇮🇱 Nahariya, HaTsafon, Israel

Sourasky Medical Center; 🇮🇱 Tel Aviv, Tell Abīb, Israel

Shaare Zedek Medical Center; 🇮🇱 Jerusalem, Yerushalayim, Israel

Fondazione Policlinico Tor Vergata; 🇮🇹 Roma, Lazio, Italy

Fondazione Policlinico Universitario Agostino Gemelli; 🇮🇹 Roma, Lazio, Italy

Humanitas; 🇮🇹 Rozzano, Lombardia, Italy

Ospedale Di Circolo; 🇮🇹 Rho, Milano, Italy

Ospedale Sandro Pertini; 🇮🇹 Rome, Roma, Italy

Azienda Ospedaliera Universitaria Pisana; 🇮🇹 Pisa, Toscana, Italy

Asahikawa City Hospital; 🇯🇵 Asahikawa, Hokkaido, Japan

Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital; 🇯🇵 Chuo-ku, Sapporo-shi, Hokkaido, Japan

Tokushukai Sapporo Tokushukai Hospital; 🇯🇵 Sapporo-shi, Hokkaido, Japan

Sapporo Higashi Tokushukai Hospital; 🇯🇵 Sapporo, Hokkaido, Japan

Aoyama Clinic GI Endoscopy & IBD Center; 🇯🇵 Kobe-shi, Hyogo-Ken, Japan

Hyogo College of Medicine; 🇯🇵 Nishinomiya, Hyogo, Japan

Mito Medical Center; 🇯🇵 Higashiibaraki, Ibaraki, Japan

Kagawa Prefectural Central Hospital; 🇯🇵 Takamatsu, Kagawa, Japan

Ofuna Central Hospital; 🇯🇵 Kamakura, Kanagawa, Japan

Kawasaki Municipal Hospital; 🇯🇵 Kawasaki, Kanagawa, Japan

Matsushima Hospital; 🇯🇵 Yokohama, Kanagawa, Japan

Yokohama City University Medical Center; 🇯🇵 Yokohama, Kanagawa, Japan

Showa University Northern Yokohama Hospital; 🇯🇵 Yokohama, Kanagawa, Japan

Mie University Hospital; 🇯🇵 Tsu, Mie, Japan

Takagi Clinic - Sendai; 🇯🇵 Sendai, Miyagi, Japan

Nagaoka Chuo General Hospital; 🇯🇵 Nagaoka, Niigata, Japan

Ishida Clinic of IBD and Gastroenterology; 🇯🇵 Oita-shi, Oita-Ken, Japan

Sai Gastroenterologist Proctology; 🇯🇵 Fujiidera, Osaka, Japan

Kumagaya General Hospital; 🇯🇵 Kumagaya-shi, Saitama-Ken, Japan

Matsuaikai Matsuda Hospital; 🇯🇵 Hamamatsu, Shizuoka, Japan

Jichi Medical University Hospital; 🇯🇵 Shimotsuke, Tochigi, Japan

Juntendo University Hospital; 🇯🇵 Bunkyo-ku, Tokyo, Japan

Tokyo Medical and Dental University Hospital; 🇯🇵 Bunkyō, Tokyo, Japan

Mitsui Memorial Hospital; 🇯🇵 Chiyoda-ku, Tokyo, Japan

Showa University Koto Toyosu Hospital; 🇯🇵 Koto-ku, Tokyo, Japan

Kitasato University Kitasato Institute Hospital; 🇯🇵 Minato-Ku, Tokyo, Japan

Kyorin University Hospital; 🇯🇵 Mitaka, Tokyo, Japan

Center Hospital of the National Center for Global Health and Medicine; 🇯🇵 Shinjyuku-ku, Tokyo, Japan

Fukuoka University Hospital; 🇯🇵 Fukuoka, Japan

Sameshima Hospital; 🇯🇵 Kagoshima, Japan

National Hospital Organization Kyoto Medical Center; 🇯🇵 Kyoto, Japan

Okayama University Hospital; 🇯🇵 Okayama, Japan

Infusion Clinic; 🇯🇵 Osaka, Japan

National Hospital Organization - Osaka National Hospital - Institute For Clinical Research; 🇯🇵 Osaka, Japan

Saga-Ken Medical Center Koseikan; 🇯🇵 Saga, Japan

Tokitokai Tokito Clinic Coloproctology Center; 🇯🇵 Saitama, Japan

Tokyo Yamate Medical Center; 🇯🇵 Tokyo, Japan

Toyama Prefectural Central Hospital; 🇯🇵 Toyama, Japan

Yonsei University-Wonju Severance Christian Hospital; 🇰🇷 Wonju, Kang-won-do, Korea, Republic of

Yeungnam Univeristy Medical Center; 🇰🇷 Gyeongsan-si, Kyǒngsangbuk-do, Korea, Republic of

Dong-A University Hospital; 🇰🇷 Busan, Pusan-Kwangyǒkshi, Korea, Republic of

Inje University Haeundae Paik Hospital; 🇰🇷 Haeundae-gu, Pusan-Kwangyǒkshi, Korea, Republic of

Kyung Hee University Hospital; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Asan Medical Center; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Kangbuk Samsung Hospital; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

Samsung Medical Center; 🇰🇷 Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of

The Catholic University of Korea, Daejeon St. Mary's Hospital; 🇰🇷 Daejeon, Taejǒn-Kwangyǒkshi, Korea, Republic of

Pauls Stradins Clinical Univeristy Hospital; 🇱🇻 Riga, Rīga, Latvia

RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia; 🇱🇻 Riga, Rīga, Latvia

Digestive Diseases Center "Gastro"; 🇱🇻 Riga, Latvia

Viesoji Istaiga Klaipedos Miesto Poliklinika; 🇱🇹 Klaipėda, Klaipėdos Miestas, Lithuania

Respublikine Panevezio ligonine; 🇱🇹 Panevezys, Panevėžio Apskritis, Lithuania

Hospital of Lithuanian University of Health Sciences Kaunas; 🇱🇹 Kaunas, Lithuania

Republic Hospital of Klaipeda; 🇱🇹 Klaipeda, Lithuania

Vilnius University Hospital Santaros Klinikos; 🇱🇹 Vilnius, Lithuania

Hospital Sultanah Bahiyah; 🇲🇾 Alor Star, Kedah, Malaysia

Hospital Raja Perempuan Zainab II; 🇲🇾 Kota Bahru, Kelantan, Malaysia

University Malaya Medical Centre; 🇲🇾 Kuala Lumpur, Malaysia

Pusat Perubatan University Kebangsaan Malaysia; 🇲🇾 Cheras, Kuala Lumpur, Malaysia

Hospital Universiti Sains Malaysia; 🇲🇾 Kubang Kerian, Malaysia

Hospital Serdang; 🇲🇾 Selangor, Malaysia

Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.; 🇲🇽 Culiacán, Sinaloa, Mexico

Scientia Investigacion Clinica S.C.; 🇲🇽 Chihuahua, Mexico

Sociedad de Metabolismo y Corazon; 🇲🇽 Veracruz, Mexico

Republican Clinical Hospital; 🇲🇩 Chisinau, Moldova, Republic of

Elisabeth-TweeSteden Ziekenhuis; 🇳🇱 Tilburg, Noord-Brabant, Netherlands

Ziekenhuis Bernhoven; 🇳🇱 Uden, Noord-Brabant, Netherlands

Amsterdam UMC, locatie VUmc; 🇳🇱 Amsterdam, Noord-Holland, Netherlands

Universitair Medisch Centrum Utrecht; 🇳🇱 Utrecht, Netherlands

LexMedica; 🇵🇱 Wroclaw, Dolnośląskie, Poland

Ars-Medica; 🇵🇱 Wroclaw, Dolnośląskie, Poland

Centrum Medyczne "Medis" Manermed; 🇵🇱 Bydgoszcz, Kujawsko-pomorskie, Poland

Centrum Medyczne Pratia Bydgoszcz; 🇵🇱 Bydgoszcz, Kujawsko-pomorskie, Poland

Gastromed; 🇵🇱 Torun, Kujawsko-pomorskie, Poland

ZOZ Gastromed; 🇵🇱 Lublin, Lubelskie, Poland

Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie; 🇵🇱 Lublin, Lubelskie, Poland

ETG Zamość; 🇵🇱 Zamosc, Lubelskie, Poland

NZOZ Vivamed; 🇵🇱 Warsaw, Mazowieckie, Poland

WIP Warsaw IBD Point Profesor Kierkus; 🇵🇱 Warsaw, Mazowieckie, Poland

Centrum Zdrowia MDM; 🇵🇱 Warszawa, Mazowieckie, Poland

Gabinet Endoskopii Przewodu Pokarmowego; 🇵🇱 Krakow, Małopolskie, Poland

Topolowa Medicenter; 🇵🇱 Krakow, Małopolskie, Poland

Medicenter Nowy Targ; 🇵🇱 Nowy Targ, Małopolskie, Poland

NZOZ Formed; 🇵🇱 Wadowice, Małopolskie, Poland

Centralny Szpital Kliniczny MSWiA w Warszawie; 🇵🇱 Warsaw, Małopolskie, Poland

Centrum Medyczne LUX MED - Rzeszow; 🇵🇱 Rzeszow, Podkarpackie, Poland

Endoskopia Sp. z.o.o.; 🇵🇱 Sopot, Pomorskie, Poland

Szpital Miejski im. Jana Pawła II w Elblagu; 🇵🇱 Elblag, Warmińsko-mazurskie, Poland

Wojewódzki Szpital Specjalistyczny w Olsztynie; 🇵🇱 Olsztyn, Warmińsko-mazurskie, Poland

Twoja Przychodnia - Szczecinskie Centrum Medyczne; 🇵🇱 Szczecin, Zachodniopomorskie, Poland

SONOMED Centrum Medyczne; 🇵🇱 Szczecin, Zachodniopomorskie, Poland

Promedica Dental Clinic; 🇵🇱 Bedzin, Śląskie, Poland

All-Medicus; 🇵🇱 Katowice, Śląskie, Poland

Spitalul Pelican; 🇷🇴 Oradea, Bihor, Romania

Spitalul de Oncologie Monza; 🇷🇴 Bucharest, București, Romania

S.C. Centrul Medical Medicum SRL; 🇷🇴 Bucuresti, București, Romania

Spitalul Clinic Colentina; 🇷🇴 Bucuresti, București, Romania

CCBR Clinical Research; 🇷🇴 Bucuresti, București, Romania

Poliklinika Agmu "Konsul'tativno-Diagnosticheskiy Tsentr"; 🇷🇺 Barnaul, Altayskiy Kray, Russian Federation

Scientific Centre of Reconstructive and Restorative Surgery; 🇷🇺 Irkutsk, Irkutskaya Oblast', Russian Federation

Karelia Republican Hospital V.A. Baranova; 🇷🇺 Petrozavodsk, Kareliya, Respublika, Russian Federation

SIH Kemerovo Regional Clinical Hosptial; 🇷🇺 Kemerovo, Kemerovskaya Oblast', Russian Federation

City Mariinskaya Hospital; 🇷🇺 Saint Petersburg, Leningradskaya Oblast', Russian Federation

Nizhny Novgorod Regional Hospital N.A. Semashko; 🇷🇺 Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation

Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod; 🇷🇺 Nizhny Novgorod, Nizhegorodskaya Oblast', Russian Federation

Medical Center SibNovoMed; 🇷🇺 Novosibirsk, Novosibirskaya Oblast', Russian Federation

Research Institute of Physiology and Fundamental Medicine; 🇷🇺 Novosibirsk, Novosibirskaya Oblast', Russian Federation

Ultramed; 🇷🇺 Omsk, Omskaya Oblast', Russian Federation

Rostov State Medical University; 🇷🇺 Rostov-on-Don, Rostovskaya Oblast', Russian Federation

North-Western State Medical University named after I.I.Mechnikov; 🇷🇺 Saint - Petersburg, Sankt-Peterburg, Russian Federation

Clinical Hospital "RZhD-Medicine"; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

Scientific research center ECO-security; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

Saint Petersburg State Budgetary Healthcare Institution City Clinical Hospital No.31; 🇷🇺 Saint Petersburg, Sankt-Peterburg, Russian Federation

First Pavlov State Medical University of Saint Petersburg; 🇷🇺 Saint-Petersburg, Sankt-Peterburg, Russian Federation

Stavropol State Medical University; 🇷🇺 Stavropol, Stavropol'skiy Kray, Russian Federation

LLC MA New Hospital; 🇷🇺 Ekaterinburg, Sverdlovskaya Oblast', Russian Federation

Kazan State Medical University; 🇷🇺 Kazan, Tatarstan, Respublika, Russian Federation

Alliance Biomedical URAL Group; 🇷🇺 Izhevsk, Udmurtskaya Respublika, Russian Federation

SHI of Yaroslavl Region Clinical Hospital #8; 🇷🇺 Yaroslavl, Yaroslavskaya Oblast', Russian Federation

Clinical Hospital Center Zvezdara; 🇷🇸 Belgrade, Beograd, Serbia

University Medical Center "Bezanijska kosa"; 🇷🇸 Belgrade, Beograd, Serbia

Regional Hospital Dr Radivoj Simonovic Sombor; 🇷🇸 Sombor, Vojvodina, Serbia

Sremska Mitrovica Health Centre; 🇷🇸 Sremska Mitrovica, Vojvodina, Serbia

General Hospital "Djordje Joanovic"; 🇷🇸 Zrenjanin, Vojvodina, Serbia

Clinical Center Kragujevac; 🇷🇸 Kragujevac, Šumadijski Okrug, Serbia

Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica; 🇸🇰 Banska Bystrica, Banskobystrický Kraj, Slovakia

Cliniq s.r.o.; 🇸🇰 Bratislava, Bratislavský Kraj, Slovakia

KM Management; 🇸🇰 Nitra, Nitriansky Kraj, Slovakia

Gastro; 🇸🇰 Prešov, Prešovský Kraj, Slovakia

Endomed, s.r.o.; 🇸🇰 Vranov N. Toplou, Prešovský Kraj, Slovakia

Hospital Universitario Central de Asturias; 🇪🇸 Oviedo, Asturias, Spain

Hospital Universitario Marqués de Valdecilla; 🇪🇸 Santander, Cantabria, Spain

Hospital Universitari de Girona Doctor Josep Trueta; 🇪🇸 Girona, Girona [Gerona], Spain

Hospital Universitario de Gran Canaria Doctor Negrín; 🇪🇸 Las Palmas De GC, Las Palmas, Spain

Hospital Universitario de Fuenlabrada; 🇪🇸 Fuenlabrada, Madrid, Spain

Hospital Universitario Son Espases; 🇪🇸 Palma De Mallorca, Palma De Mallorca(Baleares), Spain

Hospital de Sagunto y C.E.; 🇪🇸 Sagunto, València, Spain

Instituto de Ciencias Médicas; 🇪🇸 Alicante, Spain

Hospital Universitario Juan Ramon Jimenez; 🇪🇸 Huelva, Spain

Hospital Universitario La Paz; 🇪🇸 Madrid, Spain

Gastroenterologische Praxis Balsiger, Seibold & Partner; 🇨🇭 Bern, Berne, Switzerland

Cantonal Hospital St.Gallen; 🇨🇭 St.Gallen, Sankt Gallen, Switzerland

Inselspital Bern; 🇨🇭 Berne, Switzerland

UniversitätsSpital Zürich; 🇨🇭 Zürich, Switzerland

China Medical University Hospital; 🇨🇳 Taichung, Taiwan

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan

Ege University Medicine of Faculty; 🇹🇷 Bornova, İzmir, Turkey

Antalya Egitim ve Arastırma Hastanesi; 🇹🇷 Antalya, Turkey

Kocaeli Üniversitesi; 🇹🇷 Kocaeli, Turkey

Mersin University; 🇹🇷 Mersin, Turkey

Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council"; 🇺🇦 Ivano-Frankivsk, Ivano-Frankivska Oblast, Ukraine

City Clinical Hospital No. 2; 🇺🇦 Kharkiv, Kharkivska Oblast, Ukraine

L.T. Mala National Institute of Therapy of NAMS of Ukraine; 🇺🇦 Kharkiv, Kharkivska Oblast, Ukraine

Kherson City Clinical Hospital; 🇺🇦 Kherson, Khersonska Oblast, Ukraine

Private Enterprise Private Manufacturing Company Acinus; 🇺🇦 Kropyvnytskyi, Kirovohradska Oblast, Ukraine

Medical Center of Limited Liability Company "Medical Center "Consilium Medical"; 🇺🇦 Kiev, Kyiv, Ukraine

Lviv Railway Clinical Hospital; 🇺🇦 Lviv, Lvivska Oblast, Ukraine

Municipal non-profit enterprise "Lviv Territorial Medical Union "Multidisciplinary Clinical Hospital of Em -T; 🇺🇦 Lviv, Lvivska Oblast, Ukraine

Lviv Regional Clinical Hospital - Lviv National Medical University named Danylo Galician; 🇺🇦 Lviv, Lvivska Oblast, Ukraine

Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council; 🇺🇦 Odesa, Odeska Oblast, Ukraine

Poltova Oblast Clinical Hospital IM.M.V.Sklifosovskoho; 🇺🇦 Poltava, Poltavska Oblast, Ukraine

Medical Clinical Investigational Center of Medical Center Health Clinic; 🇺🇦 Vinnytsia, Vinnytska Oblast, Ukraine

City Clinical Hospital #1, Vinnitsya National Medical University; 🇺🇦 Vinnytsya, Vinnytska Oblast, Ukraine

VNMU; 🇺🇦 Vinnytsya, Vinnytska Oblast, Ukraine

Transcarpathian Regional Hospital im.Andriya Novak; 🇺🇦 Uzhgorod, Zakarpatska Oblast, Ukraine

Diaservis - Medical and Diagnostic Center; 🇺🇦 Zaporizhia, Zaporizka Oblast, Ukraine

Diacenter; 🇺🇦 Zaporizhzhia, Zaporizka Oblast, Ukraine

Municipal Nonprofit Enterprise of Kyiv Region Council "Kyiv Regional Clinical Hospital"; 🇺🇦 Kyiv, Ukraine

Medical Center Ok!Clinic+; 🇺🇦 Kyiv, Ukraine

Municipal non-profit enterprise of Kyiv Regional Council "Kyiv Regional Center for Rehabilitation Medicine"; 🇺🇦 Kyiv, Ukraine

Fairfield General Hospital; 🇬🇧 Bury, Great Britain, United Kingdom

Guy's & St Thomas' NHS Foundation Trust; 🇬🇧 London, London, City Of, United Kingdom

The John Radcliffe Hospital; 🇬🇧 Oxford, Oxfordshire, United Kingdom

Barts Health NHS Trust; 🇬🇧 London, Waltham Forest, United Kingdom