Uses of Gamma Irradiated Amniotic Membrane as an Alternative Method in Psoriasis Treatment
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Histopathological improvement
研究概览
简要总结
Using of human amniotic membrane extra-cellular matrix as a topical treatment for improving Psoriasis Area and Severity Index (PASI).
详细描述
Human amniotic membrane extra-cellular matrix was purchased from National center for radiation research and technology, Egypt, under commercial name REGE pro gel.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients have psoriasis lesion
排除标准
- •must stop other line of treatment
研究组 & 干预措施
treated
Patients who received patches of REGE pro on psoriasis lesion weekly for 8 weeks
干预措施: REGE pro (Combination Product)
结局指标
主要结局
Histopathological improvement
时间窗: 6 weeks
Two biopsies were taken from each patient before and at the end of the treatment. It was noted that all histological signs as munro's microabscess and the elongation of rete ridges were absent.
Scaling size decrement
时间窗: 2 weeks
REGE pro gel decreased scaling size in patients with sever scales to moderate scale within two weeks, scaling size decrement from moderate to mild within two weeks, and from mild to complete curing within two weeks
次要结局
- Erythema disappearing(4-6 weeks)
研究者
Nashwa Radwan
Director
Egyptian Atomic Energy Authority