NL-OMON44886
Completed
Not Applicable
The attenuation coefficient of the retinal nerve fiber layer derived from spectral domain optical coherence tomography AND diplopia in Parkinson*s disease - New OCT technique and diplopia in Parkinson's disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Parkinson's disease
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 100
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •In order to be eligible to participate in this study, a patient must meet all of the following criteria:
- •\- Clinical diagnosis of PD fulfilling the criteria of the UK PD Brain Bank (METC protocol, appendix B)
- •\- (modified) Hoehn and Yahr stage 2 \- 4 (METC protocol, appendix C) and a follow up of at least three years after diagnosis of PD.
- •\- Age 50 \- 70 years
- •\- Best\-corrected vision 20/30 or higher (using a Snellen chart)
- •\- Intra\-ocular pressure \< 21 mmHg to rule out glaucoma;In order to be eligible to participate in this study, a control subject must meet all of the following criteria:
- •\- Best\-corrected vision 20/30 or higher (using a Snellen chart)
- •\- Intra\-ocular pressure \< 21 mmHg to rule out glaucoma
Exclusion Criteria
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •\- Media opacifications
- •\- Concomitant ocular disease (glaucoma, retinal pathology, or pathology of the cornea, lens or optic nerve)
- •\- History of ocular trauma
- •\- History of laser therapy
- •\- Degenerative neurological disease other than PD.
- •\- MMSE \< 26 in healthy controls (this is a possible indication of a degenerative neurological disease)
- •\- First degree relative with PD
Outcomes
Primary Outcomes
Not specified
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