The attenuation coefficient of the retinal nerve fiber layer derived from spectral domain optical coherence tomography AND diplopia in Parkinson*s disease - New OCT technique and diplopia in Parkinson's disease

Vrije Universiteit Medisch Centrum0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年6月11日

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•In order to be eligible to participate in this study, a patient must meet all of the following criteria:
•- Clinical diagnosis of PD fulfilling the criteria of the UK PD Brain Bank (METC protocol, appendix B)
•- (modified) Hoehn and Yahr stage 2 - 4 (METC protocol, appendix C) and a follow up of at least three years after diagnosis of PD.
•- Age 50 - 70 years
•- Best-corrected vision 20/30 or higher (using a Snellen chart)
•- Intra-ocular pressure < 21 mmHg to rule out glaucoma;In order to be eligible to participate in this study, a control subject must meet all of the following criteria:
•- Best-corrected vision 20/30 or higher (using a Snellen chart)
•- Intra-ocular pressure < 21 mmHg to rule out glaucoma

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•- Media opacifications
•- Concomitant ocular disease (glaucoma, retinal pathology, or pathology of the cornea, lens or optic nerve)
•- History of ocular trauma
•- History of laser therapy
•- Degenerative neurological disease other than PD.
•- MMSE < 26 in healthy controls (this is a possible indication of a degenerative neurological disease)
•- First degree relative with PD

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