Effect of body position on retinal hemodynamic vascular change in healthy populations measuring by OCTA

Phase 1

• Conditions: general examination in normal rangenormal eye examination; OCTA; optical coherence tomohraphy angiography; retinal vascular hemodynamic; retinal vessel; Retinal vasculature; body position; head position; normal population; healthy population

• Registration Number: TCTR20200406001
• Lead Sponsor: Ratchadapisek sompoch

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-06
• Study Completion: 2021-09-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1 Healthy populations †normal physical and normal eye examination (vital signs keep body temperature <37.8c , blood pressure < 140/90 mmHg, heart rate 60 †120 beats/minute)
2 Age above or equal to 18 years
3 Normal range intraocular pressure in sitting position
4 Refractive error range from -3.00 diopter to +3.00 diopter

Exclusion Criteria

1 History of systemic vascular disease, hypertension, diabetic mellitus, cerebrovascular disease, cardiovascular disease, peripheral vascular disease
2 History of ocular disease that affect to visual acuity and ocular circulation
3 History of smoking,
4 Contraindications to prone position (cervical spine disease, cervical or back muscle strain, wound at chest or abdomen, history of congestive heart failure and obstructive sleep apnea)
5 Body weight greater than or equal to 100kg or BMI(body mass index) greater than or equal to 30
6 Waist circumference greater than or equal to 36 inches in male and greater than or equal to 32 inches in female
7 Corneal problems that cannot measure intraocular pressure by handheld tonometer (corneal scar, corneal edema)
8 Allergy to 1%tropicamide eyedrop
9 Pregnancy

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
macular perfusion density at study date optical coherence tomography angiography

Secondary Outcome Measures

Name	Time	Method
macular vessel density at study date optical coherence tomography angiography,foveal avascular zone area at study date optical coherence tomography angiography,Central subfield thickness at study date optical coherence tomography angiography program,Single point subfoveal choroidal thickness at study date optical coherence tomography angiography program,Intraocular pressure at study date measure by handheld tonometry,Systemic blood pressure at study date measure by sphygmomanometer,Ocular perfusion pressure at study date by calculation,optic nerve head perfusion at study date optical coherence tomography angiography,optic nerve head flux index at study date optical coherence tomography angiography,foveal avascular zone perimeter at study date optical coherence tomography angiography,foveal avascular zone circularity at study date optical coherence tomography angiography