A Prospective Study to Evaluate the Risk of Recurrence of Cervical Artery Dissection During Subsequent Pregnancies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 91
- 试验地点
- 1
- 主要终点
- Recurrence of CAD during pregnancy, childbirth or puerperium
研究概览
简要总结
Cervical artery dissection (CAD) accounts for about 2% of all strokes, and is a major cause of stroke in young people (about 15%). Many cases of CAD during pregnancy and puerperium have been described, suggesting that pregnancy and puerperium may be potential risk factors for CAD. The purpose of this study is to determine whether pregnancy and puerperium are also recurrence risk factors for CAD.
详细描述
In this study, all women of childbearing age who had had a CAD between 2005 and 2017 are selected. Women are identified using the ICD10 diagnostic coding system. In addition, a text search with key words ("cervical or carotid or vertebral dissection") has been created in a data warehouse of the University Hospital of Nantes.
To determine the recurrence of CAD during pregnancy and puerperium, the participating women will be asked to answer to a questionnaire, by phone or mail. The questionnaire will be conducted by the same investigator, an experienced neurologist. Information about recurrence of CAD, number of pregnancies before and after the event will be recorded, as well as, the site of obstetrical monitoring, way of delivery, and management of antithrombotics, in case of further pregnancy. In case of no further pregnancy after the dissection, the reason will be explored.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Extracranial carotid or vertebral dissection
- •Symptomatic dissection (with symptom onset within the last four weeks)
- •Spontaneous dissection
- •Imaging evidence of dissection on MRI/MRA, CTA or ultrasound.
排除标准
- •Minors or adults under guardianship
- •Intracranial artery dissection
- •Traumatic or iatrogenic dissection
- •Patient refusal to participate
结局指标
主要结局
Recurrence of CAD during pregnancy, childbirth or puerperium
时间窗: Day 0
This primary study endpoint will be evaluated by a questionnaire asked directly to participating women.
次要结局
- To determine the absolute risk of recurrence of CAD in this population.(Day 0)
- To assess obstetrical monitoring, way of delivery, and management of antithrombotics during further pregnancy.(Day 0)
- To study the reasons of absence of pregnancy after a history of CAD(Day 0)