NCT03335514CompletedNot Applicable
Changes of GALNT4 and the Relationship With PSGL-1on Monocytes and Hs-CRP in Blood of Patients With Coronary Heart Disease
The First Affiliated Hospital of Dalian Medical University1 site in 1 country100 target enrollmentStarted: September 1, 2017Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- the expression of GALNT4
Study Overview
Brief Summary
The expression of GALNT4 in blood with acute coronary syndrome
Detailed Description
Emerging evidences have linked GALNTs to cardiovascular disease or susceptibility to CAD.GALNT4, a member of the GalNAc-Ts family,contributes to the initiation of O-linked. Polymorphisms in GALNT4 have been linked with incidence of MI in an Irish population, probably that O-glycosylation of PSGL-1 by GalNAc-T4 may be important for many P-selectin mediated inflammation.However, there is few relevant studies about the expression of GALNT4 in patients with acute coronary syndrome.This study valuates the expression of GALNT4 in patients with acute coronary syndrome.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •diagnosed as acute coronary syndrome,including STEMI,NSTE-ACS,or diagnosed as SAP by CAG.
- •with left ventricular ejection fraction（LVEF）>=45%
- •written informed consents are obtained
- •admitted within 24 hours after chest pain attacked(except SAP)
Exclusion Criteria
- •• complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy
- •complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
- •with acute or chronic infection, surgery or trauma in the last month
- •secondary hypertension, severe liver dysfunction,severe renal insufficiency
- •with abnormal thyroid function or allergy to iodine agent
- •refusal to sign the informed consent
Outcomes
Primary Outcomes
the expression of GALNT4
Time Frame: 12 months
Realtime RCR measure the expression of galnt4 in peripheral blood
Secondary Outcomes
- MACEs during 12-month follow-up(12 months)
Investigators
Study Sites (1)
Loading locations...
Similar Trials
Not yet recruiting
Not Applicable
Identification of Serum Level of Glutathione Peroxidase 4SpondyloarthropathyNCT06554392Assiut University85
Withdrawn
Not Applicable
Interleukin-4 (IL-4) as a Marker of AtherosclerosisIschemic Heart DiseaseAtherosclerosisNCT00256035Melbourne Health
Unknown
Not Applicable
Plasmablast Detection From IgG4-Related Disease PatientsIgG4-related DiseaseNCT03466970Meir Medical Center40
Unknown
Not Applicable
The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome PatientsChronic Coronary Artery DiseaseAcute Coronary SyndromeNCT01255267China Medical University Hospital
Completed
Not Applicable
Prognostic Value of Plasma DPP4 Activity in ST-elevation Myocardial Infarction PatientsCoronary AngiographyDipeptidyl Peptidase 4NCT03046576Chinese PLA General Hospital625