Comparing the effect of Antipsychotic drugs with or without Cobalamin in elimination of pain and symptoms of psychosis in Alzheimer's patients

Not Applicable

Completed

• Conditions: Alzheimer disease.; Alzheimer disease

• Registration Number: IRCT201501101061N18
• Lead Sponsor: Rafsanjan University of Medical Siences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Alzheimer diagnosis in elderly patients is carried out on basis of clinical interviews; DSM IV diagnosis criteria; medical history; clinical examinations; MRI and brain CT scan results and the mini mental state examination score; Patients who have mini mental score above than are studied; patient with Brief Psychiatric Rating Scale score 30-70. Exclusion criteria Patients who were taking anti-psychotic medication; has schizophrenia symptoms; preliminary psychotic disorders; delirium; psychoses followed by drug or medication take; Other medical background disorders like B12 deficiency and hypothyroidism; Patients needed to be hospitalized; Patients posed to suicide commitment risk; Other causes of dementia like brain tumors; strokes; normal pressure hydrocephalus; Underlying medical conditions; that may cause behavioral or psychotic symptoms or delirium such as infection, medications with anticholinergic effects; corticosteroid use; or neurological insults is the first step in the decision-making process for treatment. In addition, the patients were discarded from the procedure if they need further medical intervention and other drugs according to their health status or families’ remark

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: before treatment , 2 weeks and 8 weeks after treatment. Method of measurement: Visual Analogue Scale for pain Questionnaire.;Psychiatric symptoms. Timepoint: before treatment , 2 weeks and 8 weeks after treatment. Method of measurement: Breif Psychiatric Rating Scale Questionnaire.

Secondary Outcome Measures

Name	Time	Method
Patient progress and treatment response. Timepoint: 2 weeks and 8 weeks after treatment. Method of measurement: Clinical Global Impressions scale Questionnaire.