Development of treatment model and verification of a new integrated clinical subtype based on multi-dementional analysis on the common and differential mechanisms of cognitive dysfunction and depression in cognitive dysfunction with depression.

Hallym University Medical Center- Chuncheon0 个研究点目标入组 500 人开始时间: 待定最近更新: 2022年5月30日

适应症

试验速览

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•1) Patients over 55 years of age.
•2) A person who meets the diagnosis based on the following medical diagnosis.
•- Diagnosis of Alzheimer's dementia and mild cognitive impairment: A patient diagnosed based on the diagnostic criteria of DSM-V and diagnostic impressions of CERAD-K (Korean Version of the Concortium to Establish a Registry of Alzheimer's Disease) evaluation.
•- Depression Diagnosis: Patients diagnosed with major depressive disorder, minor depressive disorder, and subsymptomatic depressive disorder using MINI-K.
•3) In the normal group, except for 2).
•4) A person who can voluntarily decide to participate in this clinical trial, give written consent, and perform clinical procedures including filling out questionnaires. However, if the patient is unable to make a voluntary decision due to cognitive decline, his/her legal representative may decide to participate.

•1) Persons with serious medical illnesses (heart failure, angina pectoris, myocardial infarction, arteriosclerosis, diabetes, inflammatory disease, malignancy, etc.) or psychiatric disease other than AD and MCI diagnosis.
•2) Those diagnosed with bipolar or psychotic major depressive disorder.
•3) Those with a history of seizures, brain surgery, organic brain disease or organic emotional disorder, and abnormal findings other than brain atrophy on brain MRI.
•4) Those who are judged to have problems attaching EEG patches and near-infrared electrodes due to scalp deformities, inflammatory reactions, or other dermatological problems.
•5) Those with a history of habitual drinking or drug abuse.
•6) Patients with uncontrolled diabetes or hypertension.
•7) Those who are judged to be inappropriate for this clinical trial by the investigator.
•8) Patients with severe dementia (GDS score of 7 or higher or CDR score of 4 or higher).

发起方

Hallym University Medical Center- Chuncheon