Evaluation of Skin Stiffness Changes in Wounds Before and After Low-Level Laser Therapy

Not Applicable

Active, not recruiting

• Conditions: Wound - in Medical Care

• Registration Number: NCT07177274
• Lead Sponsor: Asia University

Brief Summary

Chronic wounds and impaired healing remain a major clinical challenge, particularly in patients with diabetes, vascular disease, or age-related skin fragility. Low-level laser therapy (LLLT) at 660 nm has been reported to enhance tissue repair, reduce inflammation, and promote angiogenesis. However, the biomechanical properties of wound tissue following LLLT remain poorly understood.

Optical Coherence Tomography (OCT) provides a non-invasive, high-resolution method to assess skin microstructure and elasticity, while the MyotonPRO offers quantitative stiffness measurements at the tissue surface. Combining these two complementary modalities may provide a more comprehensive assessment of wound healing progression and treatment response.

This study aims to evaluate changes in wound stiffness before and after 660 nm LLLT and to compare them against contralateral normal skin, thereby providing objective insight into the biomechanical efficacy of laser treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-09-19
• Primary Completion: 2025-07-24
• Status Verified: 2025-09
• Study First Submitted: 2025-09-10
• Study First Submitted QC: 2025-09-10
• Last Update Submitted: 2025-09-10
• Study First Posted: 2025-09-16
• Last Update Posted: 2025-09-16
• Study Completion: 2025-09-20

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• presented chronic and burn wounds lasting more than four weeks.
• had partial-thickness burn wounds.

Exclusion Criteria

• current smokers.
• wounds that were fresh and still bleeding.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
To evaluate changes in skin stiffness of wound tissue before and after LLLT using OCT and MyotonPRO.	1 year

Secondary Outcome Measures

Name	Time	Method
To compare wound skin stiffness with contralateral normal skin.	1 year	To assess differences in stiffness response between upper-body and lower-body wound sites.; To determine the correlation between OCT and MyotonPRO stiffness measurements.

Trial Locations

Locations (1)

Asia University; 🇨🇳 Taichung, Wufeng, Taiwan