Influence of Intraoperative Blood Salvage and Autotransfusion on Tumor Recurrence After Deceased Donor Liver Transplantation

Completed

• Conditions: Liver Transplant; Complications

• Registration Number: NCT06307158
• Lead Sponsor: Zhejiang University

Brief Summary

The practice of intraoperative blood salvage and autotransfusion (IBSA) during deceased donor liver transplantation (DDLT) for hepatocellular carcinoma (HCC) can potentially reduce the need for allogeneic blood transfusion. However, implementing IBSA remains debatable due to concerns about its possible detrimental effects on oncologic recurrence. Hence, a nationwide multi-center study was conducted to investigate further the association between IBSA and post-transplant HCC recurrence, including a stratified subgroup analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2020-12-31
• Study Completion: 2021-12-31
• Status Verified: 2024-03
• Study First Submitted: 2024-03-06
• Study First Submitted QC: 2024-03-06
• Last Update Submitted: 2024-03-06
• Study First Posted: 2024-03-12
• Last Update Posted: 2024-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 998

Inclusion Criteria

• adult-to-adult deceased donor liver transplantation for hepatocellular carcinoma

Exclusion Criteria

• patients under 18 years of age
• presence of extrahepatic metastasis
• combined kidney transplantation
• reduced-size or split liver transplantation
• re-transplantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative recurrence of liver cancer	2015.1.1-2020.12.31	The overall incidence of HCC recurrence (intrahepatic or extrahepatic) after LT.