A Randomized, Controlled, Open-label Study to Investigate the Impact of Disease Activity and Nutrition Treat on Postoperative Recurrence and Complications After Bowel Resection for Crohn's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Crohn's Disease
- Sponsor
- Jinling Hospital, China
- Enrollment
- 91
- Locations
- 1
- Primary Endpoint
- postoperative complications
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The study was aimed to determine whether perioperative nutrition treat and(or)the perioperative disease activity were associated with postoperative recurrence and complications after bowel resection for Crohn's disease.
Detailed Description
The investigators want to assess the impact of possible risk factors on intestinal resection and postoperative recurrence in Crohn's disease (CD) and to evaluate the disease course. In our clinical treatments, the investigators found that perioperative CDAI and nutrition treatment may have same impact on postoperative recurrence and complication in Crohn's disease. The investigators design this study to test it. The study prepare to collect the clinical data of patients who need bowel resection for CD to analyzed. The investigators divide those patients into two groups (N,I group). They accept intestinal nutrition with the respective aim that get the inflammatory index (erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Crohns Disease Activity Index (CDAI)) norm or nutritional index norm before they accept surgery. Postoperative recurrence and complications in patients will be recorded and compared.
Investigators
Zhu Weiming
vice director of General surgery institute
Jinling Hospital, China
Eligibility Criteria
Inclusion Criteria
- •Patients had a CRP level of more than 8mg/L Patients had a preoperative weight loss \>5% over the past 6 months and had a serum albumin of less than 35g/L at the enrollment
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
postoperative complications
Time Frame: 4 weeks
Secondary Outcomes
- postoperative recurrence(52 weeks)